Genomic landscape of breast cancer in elderly patients

Genomic landscape of breast cancer in elderly patients

Abstract Breast cancer (BC) displays age-related histopathologic and transcriptomic heterogeneity. Whether BC in elderly patients differs genetically from that of younger individuals remains unclear. We re-analyzed sequencing data from 1918 BCs previously subjected to an FDA-cleared paired tumor-nor...

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Main Authors: Pier Selenica, Higinio Dopeso, Matteo Repetto, Thais Basili, Andrea M. Gazzo, Christopher J. Schwartz, Fatemeh Derakhshan, Antonio Marra, Lorenzo Ferrando, Regina G. H. Beets-Tan, Y. H. Wen, Dara S. Ross, Edi Brogi, Hong Zhang, Larry Norton, Sarat Chandarlapaty, Pedram Razavi, Diana Mandelker, Jorge S. Reis-Fiho, Britta Weigelt, Fresia Pareja
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00781-4
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