Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease
Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying levels. Objective: To analyze the association between the serum brain-derived neurotrophic factor levels...
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| Format: | Article |
| Language: | English |
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Universidad de Ciencias Médicas de La Habana
2024-03-01
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| Series: | Revista Habanera de Ciencias Médicas |
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| Online Access: | https://revhabanera.sld.cu/index.php/rhab/article/view/5179 |
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| author | Naybí Prendes Rivero Levis Verde Corvo Belkis López González Iris Dany Carmenate Rodríguez Nibaldo B Mesa Hernández María A Robinson Agramonte |
| author_facet | Naybí Prendes Rivero Levis Verde Corvo Belkis López González Iris Dany Carmenate Rodríguez Nibaldo B Mesa Hernández María A Robinson Agramonte |
| author_sort | Naybí Prendes Rivero |
| collection | DOAJ |
| description | Introduction: The brain derived neurotrophic factor is a neurotrophin
modulator of cognitive processes. Current studies in Alzheimer’s disease
patients show alterations in biomarkers at outlying levels.
Objective: To analyze the association between the serum brain-derived neurotrophic factor levels and the cognitive markers in Alzheimer’s disease subjects.
Material and Methods: A correlational transversal study was conducted in subjects aged 64 years, distributed into three groups: group 1ː16 controls, group 2ː27 with mild cognitive impairment, and group 3ː21 with Alzheimer’s disease. A neuropsychological test battery, and the immunoenzymatic method (ELISA), Promega Emax Kit were applied to determine the serum brain-derived neurotrophic factor levels. The statistical analysis of data was performed using the one-way ANOVA test, the post-hoc Dunnett´s test and the Pearson’s correlation coefficient (p<0.05).
Results: The serum brain-derived neurotrophic factor levels were lower in the groups with Alzheimer’s disease and mild cognitive impairment. The factor levels were correlated with the episodic memory, the executive functions, and the global cognitive function in Alzheimer’s disease patients. In the mild cognitive impairment group, the serum brain-derived neurotrophic factor was only associated with the executive functionl.
Conclusions: The serum brain-derived neurotrophic factor levels diminish in association with cognitive impairment in Alzheimer’s disease. Furthermore, this factor linked to the executive domain dysfunction is suggested as a potential biomarker of neuroplasticity in the preclinical detection of this pathology. |
| format | Article |
| id | doaj-art-0ef0af1b7c7b42b0babd1b4908e5cfed |
| institution | Kabale University |
| issn | 1729-519X |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Universidad de Ciencias Médicas de La Habana |
| record_format | Article |
| series | Revista Habanera de Ciencias Médicas |
| spelling | doaj-art-0ef0af1b7c7b42b0babd1b4908e5cfed2025-08-20T03:26:10ZengUniversidad de Ciencias Médicas de La HabanaRevista Habanera de Ciencias Médicas1729-519X2024-03-01225e5179e51792148Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s diseaseNaybí Prendes Rivero0Levis Verde Corvo1Belkis López González2Iris Dany Carmenate Rodríguez3Nibaldo B Mesa Hernández4María A Robinson Agramonte5Hospital General Docente Iván Portuondo, Departamento de Medicina Legal. Artemisa.Sede docente municipal de San Antonio de los Baños, Sección de Docencia e Investigación. Artemisa.Hospital Universitario “General Calixto García”. La Habana.Hospital Infantil de Santi Spiritus, Universidad de Ciencias Médicas de Santi Spiritus, Santi Spiritus.Universidad de Ciencias Médicas de La Habana, Facultad de Ciencias Médicas Victoria de Girón. La Habana.Centro International de Restauración Neurológica. La Habana.Introduction: The brain derived neurotrophic factor is a neurotrophin modulator of cognitive processes. Current studies in Alzheimer’s disease patients show alterations in biomarkers at outlying levels. Objective: To analyze the association between the serum brain-derived neurotrophic factor levels and the cognitive markers in Alzheimer’s disease subjects. Material and Methods: A correlational transversal study was conducted in subjects aged 64 years, distributed into three groups: group 1ː16 controls, group 2ː27 with mild cognitive impairment, and group 3ː21 with Alzheimer’s disease. A neuropsychological test battery, and the immunoenzymatic method (ELISA), Promega Emax Kit were applied to determine the serum brain-derived neurotrophic factor levels. The statistical analysis of data was performed using the one-way ANOVA test, the post-hoc Dunnett´s test and the Pearson’s correlation coefficient (p<0.05). Results: The serum brain-derived neurotrophic factor levels were lower in the groups with Alzheimer’s disease and mild cognitive impairment. The factor levels were correlated with the episodic memory, the executive functions, and the global cognitive function in Alzheimer’s disease patients. In the mild cognitive impairment group, the serum brain-derived neurotrophic factor was only associated with the executive functionl. Conclusions: The serum brain-derived neurotrophic factor levels diminish in association with cognitive impairment in Alzheimer’s disease. Furthermore, this factor linked to the executive domain dysfunction is suggested as a potential biomarker of neuroplasticity in the preclinical detection of this pathology.https://revhabanera.sld.cu/index.php/rhab/article/view/5179factor neurotrófico derivado del cerebromemoria episódicafunción ejecutivadeterioro cognitivo leveenfermedad de alzheimer |
| spellingShingle | Naybí Prendes Rivero Levis Verde Corvo Belkis López González Iris Dany Carmenate Rodríguez Nibaldo B Mesa Hernández María A Robinson Agramonte Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease Revista Habanera de Ciencias Médicas factor neurotrófico derivado del cerebro memoria episódica función ejecutiva deterioro cognitivo leve enfermedad de alzheimer |
| title | Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease |
| title_full | Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease |
| title_fullStr | Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease |
| title_full_unstemmed | Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease |
| title_short | Brain Derived Neurotrophic Factor and cognitive markers in subjects with Alzheimer’s disease |
| title_sort | brain derived neurotrophic factor and cognitive markers in subjects with alzheimer s disease |
| topic | factor neurotrófico derivado del cerebro memoria episódica función ejecutiva deterioro cognitivo leve enfermedad de alzheimer |
| url | https://revhabanera.sld.cu/index.php/rhab/article/view/5179 |
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