Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus)
Bee venom (BV) has been widely studied for its therapeutic properties in various medical applications. However, its effects on aquatic organisms, particularly Nile tilapia (Oreochromis niloticus), remain poorly understood, particularly concerning toxicity and therapeutic impacts. This study investig...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-05-01
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| Series: | Aquaculture and Fisheries |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468550X24000200 |
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| author | Mohammed F. El Basuini Haitham M. Ramadan Abdelaziz M. El-Hais Mohamed A.A. Zaki Nourhan M. Kamel Islam I. Teiba Emad H. El-Bilawy Mohamed Reda Badr Mohamed Fathy Abdel-Aziz Akram Ismael Shehata |
| author_facet | Mohammed F. El Basuini Haitham M. Ramadan Abdelaziz M. El-Hais Mohamed A.A. Zaki Nourhan M. Kamel Islam I. Teiba Emad H. El-Bilawy Mohamed Reda Badr Mohamed Fathy Abdel-Aziz Akram Ismael Shehata |
| author_sort | Mohammed F. El Basuini |
| collection | DOAJ |
| description | Bee venom (BV) has been widely studied for its therapeutic properties in various medical applications. However, its effects on aquatic organisms, particularly Nile tilapia (Oreochromis niloticus), remain poorly understood, particularly concerning toxicity and therapeutic impacts. This study investigated the effects of bee venom (BV) injection on Nile tilapia (O. niloticus) by examining growth, feed efficiency, biometric parameters, whole-body chemical analysis, and the activity of antioxidant enzymes in the liver. Nile tilapia juveniles were injected with BV at doses of 0, 3, 6, 9, and 12 mg/kg of fish weight. Observations were made on the 14th day post-injection (DPI). No significant differences were found in growth, feed utilization, survival rate, biometric indices, and whole-body composition among the BV dosage groups. Similarly, the activity of intestinal enzymes (amylase, protease, and lipase) showed no significant changes. However, the study revealed a time-dependent response of antioxidant enzymes (SOD, CAT, and GPx) in the liver, with activity peaks on the 4th and 6th DPI. On the 14th DPI, fish injected with BV at doses of 3, 6, and 9 mg/kg exhibited higher antioxidant enzyme activities compared to the control and the highest dosage group (12 mg/kg). These results imply the presence of potential adaptive antioxidant activity and a favorable influence on the health and immune responses of Nile tilapia following BV injection. Notably, the effects appear to vary with the dose, influencing both antioxidant enzyme activities and immunity. Further research is warranted to explore the long-term effects of BV exposure and its potential therapeutic applications in aquaculture. |
| format | Article |
| id | doaj-art-0ef052dddfbe465a82f4f2a8086d2a71 |
| institution | OA Journals |
| issn | 2468-550X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Aquaculture and Fisheries |
| spelling | doaj-art-0ef052dddfbe465a82f4f2a8086d2a712025-08-20T02:30:10ZengKeAi Communications Co., Ltd.Aquaculture and Fisheries2468-550X2025-05-0110342944110.1016/j.aaf.2024.02.002Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus)Mohammed F. El Basuini0Haitham M. Ramadan1Abdelaziz M. El-Hais2Mohamed A.A. Zaki3Nourhan M. Kamel4Islam I. Teiba5Emad H. El-Bilawy6Mohamed Reda Badr7Mohamed Fathy Abdel-Aziz8Akram Ismael Shehata9Faculty of Agriculture, Tanta University, Tanta, 31527, Egypt; King Salman International University, South Sinai, 46612, Egypt; Corresponding author. Faculty of Agriculture, Tanta University, Tanta, 31527, Egypt.Faculty of Agriculture, Tanta University, Tanta, 31527, EgyptFaculty of Agriculture, Tanta University, Tanta, 31527, EgyptDepartment of Animal and Fish Production, Faculty of Agriculture, Alexandria University, El-Shatby, 21545, EgyptFaculty of Agriculture, Tanta University, Tanta, 31527, EgyptFaculty of Agriculture, Tanta University, Tanta, 31527, EgyptKing Salman International University, South Sinai, 46612, EgyptFaculty of Agriculture, Tanta University, Tanta, 31527, EgyptDepartment of Aquaculture and Biotechnology, Faculty of Aquaculture and Marine Fisheries, Arish University, Arish, 45511, EgyptDepartment of Animal and Fish Production, Faculty of Agriculture (Saba Basha), Alexandria University, Alexandria, 21531, EgyptBee venom (BV) has been widely studied for its therapeutic properties in various medical applications. However, its effects on aquatic organisms, particularly Nile tilapia (Oreochromis niloticus), remain poorly understood, particularly concerning toxicity and therapeutic impacts. This study investigated the effects of bee venom (BV) injection on Nile tilapia (O. niloticus) by examining growth, feed efficiency, biometric parameters, whole-body chemical analysis, and the activity of antioxidant enzymes in the liver. Nile tilapia juveniles were injected with BV at doses of 0, 3, 6, 9, and 12 mg/kg of fish weight. Observations were made on the 14th day post-injection (DPI). No significant differences were found in growth, feed utilization, survival rate, biometric indices, and whole-body composition among the BV dosage groups. Similarly, the activity of intestinal enzymes (amylase, protease, and lipase) showed no significant changes. However, the study revealed a time-dependent response of antioxidant enzymes (SOD, CAT, and GPx) in the liver, with activity peaks on the 4th and 6th DPI. On the 14th DPI, fish injected with BV at doses of 3, 6, and 9 mg/kg exhibited higher antioxidant enzyme activities compared to the control and the highest dosage group (12 mg/kg). These results imply the presence of potential adaptive antioxidant activity and a favorable influence on the health and immune responses of Nile tilapia following BV injection. Notably, the effects appear to vary with the dose, influencing both antioxidant enzyme activities and immunity. Further research is warranted to explore the long-term effects of BV exposure and its potential therapeutic applications in aquaculture.http://www.sciencedirect.com/science/article/pii/S2468550X24000200Bee venomNile tilapiaGrowthImmunoglobulinAntioxidant enzymesOxidative stress |
| spellingShingle | Mohammed F. El Basuini Haitham M. Ramadan Abdelaziz M. El-Hais Mohamed A.A. Zaki Nourhan M. Kamel Islam I. Teiba Emad H. El-Bilawy Mohamed Reda Badr Mohamed Fathy Abdel-Aziz Akram Ismael Shehata Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) Aquaculture and Fisheries Bee venom Nile tilapia Growth Immunoglobulin Antioxidant enzymes Oxidative stress |
| title | Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) |
| title_full | Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) |
| title_fullStr | Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) |
| title_full_unstemmed | Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) |
| title_short | Toxicity and therapeutical impacts of Bee venom (Apis mellifera L.) on Nile tilapia juvenile (Oreochromis niloticus) |
| title_sort | toxicity and therapeutical impacts of bee venom apis mellifera l on nile tilapia juvenile oreochromis niloticus |
| topic | Bee venom Nile tilapia Growth Immunoglobulin Antioxidant enzymes Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2468550X24000200 |
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