Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center
Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics we...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2013-11-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856&lng=en&tlng=en |
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| author | Priscila de Freitas-Lima Andre de Oliveira Baldoni Veriano Alexandre Leonardo Regis Leira Pereira Americo Ceiki Sakamoto |
| author_facet | Priscila de Freitas-Lima Andre de Oliveira Baldoni Veriano Alexandre Leonardo Regis Leira Pereira Americo Ceiki Sakamoto |
| author_sort | Priscila de Freitas-Lima |
| collection | DOAJ |
| description | Objective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system. |
| format | Article |
| id | doaj-art-0eeb5e3314654cc9bfb0acf2e12ddea9 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2013-11-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-0eeb5e3314654cc9bfb0acf2e12ddea92025-08-20T02:02:26ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272013-11-01711185686110.1590/0004-282X20130169S0004-282X2013001200856Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral centerPriscila de Freitas-LimaAndre de Oliveira BaldoniVeriano AlexandreLeonardo Regis Leira PereiraAmerico Ceiki SakamotoObjective To evaluate the utilization profile of antiepileptic drugs in a population of adult patients with refractory epilepsy attending a tertiary center. Method Descriptive analyses of data were obtained from the medical records of 112 patients. Other clinical and demographic characteristics were also registered. Results Polytherapies with ≥3 antiepileptic drugs were prescribed to 60.7% of patients. Of the old agents, carbamazepine and clobazam were the most commonly prescribed (72.3% and 58.9% of the patients, respectively). Among the new agents, lamotrigine was the most commonly prescribed (36.6% of the patients). At least one old agent was identified in 103 out of the 104 polytherapies, while at least one new agent was prescribed to 70.5% of the population. The most prevalent combination was carbamazepine + clobazam + lamotrigine. The mean AED load found was 3.3 (range 0.4–7.7). Conclusion The pattern of use of individual drugs, although consistent with current treatment guidelines, is strongly influenced by the public health system.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856&lng=en&tlng=enepilepsiaepilepsia refratariafarmacos antiepilepticospoliterapiautilizacao de farmacos |
| spellingShingle | Priscila de Freitas-Lima Andre de Oliveira Baldoni Veriano Alexandre Leonardo Regis Leira Pereira Americo Ceiki Sakamoto Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center Arquivos de Neuro-Psiquiatria epilepsia epilepsia refrataria farmacos antiepilepticos politerapia utilizacao de farmacos |
| title | Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| title_full | Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| title_fullStr | Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| title_full_unstemmed | Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| title_short | Drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| title_sort | drug utilization profile in adult patients with refractory epilepsy at a tertiary referral center |
| topic | epilepsia epilepsia refrataria farmacos antiepilepticos politerapia utilizacao de farmacos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001200856&lng=en&tlng=en |
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