Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction
Background. The end point of this study was to investigate the prevalence of MS in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone levels. Methods. This case-control study included 65 patients, 37 with erectile dys...
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/272769 |
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| author | Miguel Ángel Arrabal-Polo Salvador Arias-Santiago Fernando López-Carmona Pintado Sergio Merino-Salas Clara Lahoz-García Armando Zuluaga-Gómez Miguel Arrabal-Martin |
| author_facet | Miguel Ángel Arrabal-Polo Salvador Arias-Santiago Fernando López-Carmona Pintado Sergio Merino-Salas Clara Lahoz-García Armando Zuluaga-Gómez Miguel Arrabal-Martin |
| author_sort | Miguel Ángel Arrabal-Polo |
| collection | DOAJ |
| description | Background. The end point of this study was to investigate the prevalence of MS in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone levels. Methods. This case-control study included 65 patients, 37 with erectile dysfunction, according to the International Index of Erectile Function (IIEF) from the Urology Department of San Cecilio University Hospital, Granada (Spain) and 28 healthy controls. The prevalence of metabolic syndrome was calculated according to ATP-III criteria. Hormone levels and acute phase parameters were studied in samples drawn. Results. The ATP-III criteria for MS were met by 64.9% of the patients with ED and only 9.5% of the controls (P<0.0001, OR = 17.53, 95% CI: 3.52–87.37). Binary logistic regression analysis showed a strong association between patients with ED and MS, even after additional adjustment for confounding factors (OR = 20.05, 95% CI: 1.24–32.82, P<0.034). Patients with hypogonadism presented a significantly higher prevalence of metabolic syndrome. Multiple linear regression analysis showed that systolic BP and CRP predicted 0.46 (model R2) of IIEF changes. Conclusion. Chronic inflammation found in patients with ED might explain the association between ED and metabolic syndrome. |
| format | Article |
| id | doaj-art-0eeaebcbe3f34e2eb5caf013e02263ba |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0eeaebcbe3f34e2eb5caf013e02263ba2025-08-20T02:02:26ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/272769272769Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile DysfunctionMiguel Ángel Arrabal-Polo0Salvador Arias-Santiago1Fernando López-Carmona Pintado2Sergio Merino-Salas3Clara Lahoz-García4Armando Zuluaga-Gómez5Miguel Arrabal-Martin6Urology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainDepartment of Medicine, Faculty of Medicine, Granada University, Granada, SpainUrology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainUrology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainUrology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainUrology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainUrology Department, San Cecilio University Hospital, Camino de Ronda street, 143, 18003 Granada, SpainBackground. The end point of this study was to investigate the prevalence of MS in patients with ED in comparison with control subjects and to analyse the association with acute phase reactants (CRP, ESR) and hormone levels. Methods. This case-control study included 65 patients, 37 with erectile dysfunction, according to the International Index of Erectile Function (IIEF) from the Urology Department of San Cecilio University Hospital, Granada (Spain) and 28 healthy controls. The prevalence of metabolic syndrome was calculated according to ATP-III criteria. Hormone levels and acute phase parameters were studied in samples drawn. Results. The ATP-III criteria for MS were met by 64.9% of the patients with ED and only 9.5% of the controls (P<0.0001, OR = 17.53, 95% CI: 3.52–87.37). Binary logistic regression analysis showed a strong association between patients with ED and MS, even after additional adjustment for confounding factors (OR = 20.05, 95% CI: 1.24–32.82, P<0.034). Patients with hypogonadism presented a significantly higher prevalence of metabolic syndrome. Multiple linear regression analysis showed that systolic BP and CRP predicted 0.46 (model R2) of IIEF changes. Conclusion. Chronic inflammation found in patients with ED might explain the association between ED and metabolic syndrome.http://dx.doi.org/10.1100/2012/272769 |
| spellingShingle | Miguel Ángel Arrabal-Polo Salvador Arias-Santiago Fernando López-Carmona Pintado Sergio Merino-Salas Clara Lahoz-García Armando Zuluaga-Gómez Miguel Arrabal-Martin Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction The Scientific World Journal |
| title | Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction |
| title_full | Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction |
| title_fullStr | Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction |
| title_full_unstemmed | Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction |
| title_short | Metabolic Syndrome, Hormone Levels, and Inflammation in Patients with Erectile Dysfunction |
| title_sort | metabolic syndrome hormone levels and inflammation in patients with erectile dysfunction |
| url | http://dx.doi.org/10.1100/2012/272769 |
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