Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study
Introduction Brazil is a large country, with a population of mixed ethnic background and broad variation in dietary and physical activity traits across its five main regions. Because data on Brazilian women with polycystic ovary syndrome (PCOS) are still scarce, a nation-wide collaborative study was...
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BMJ Publishing Group
2019-10-01
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| author | Poli Mara Spritzer Lucas B Marchesan Betânia R Santos Felipe V Cureau Karen Oppermann Rosana Maria dos Reis Rui A Ferriani Rita Weiss Ricardo Meirelles Ana Lucia Candido Fernando M Reis Ana Luiza L. Rocha Edmund C Baracat Gustavo AR Maciel Gustavo Mafaldo Soares Hélio Haddad Filho Ivanice Gemelli Jose M Soares Junior Ramon B Ramos Sebastião F de Medeiros Técia Maria de Oliveira |
| author_facet | Poli Mara Spritzer Lucas B Marchesan Betânia R Santos Felipe V Cureau Karen Oppermann Rosana Maria dos Reis Rui A Ferriani Rita Weiss Ricardo Meirelles Ana Lucia Candido Fernando M Reis Ana Luiza L. Rocha Edmund C Baracat Gustavo AR Maciel Gustavo Mafaldo Soares Hélio Haddad Filho Ivanice Gemelli Jose M Soares Junior Ramon B Ramos Sebastião F de Medeiros Técia Maria de Oliveira |
| author_sort | Poli Mara Spritzer |
| collection | DOAJ |
| description | Introduction Brazil is a large country, with a population of mixed ethnic background and broad variation in dietary and physical activity traits across its five main regions. Because data on Brazilian women with polycystic ovary syndrome (PCOS) are still scarce, a nation-wide collaborative study was designed to determine the prevalence of metabolic and reproductive abnormalities and the presence of anxiety and depression in Brazilian women with PCOS. In addition, the study aims at describing how these characteristics are distributed across PCOS phenotypes and at detecting associations with regional demographic and lifestyle aspects, genetic variants, and epigenetic markers.Methods and analysis The Brazilian PCOS study is being conducted in the outpatient clinics of eight university hospitals within the public healthcare network (Unified Health System) across the country. Additional centres will be included following completion of the research ethics approval process. The sample includes women with PCOS according to Rotterdam criteria at inclusion in the study and a control group of healthy women matched by age, socioeconomic status and geographical region. Data will be collected in each centre and incorporated into a unified cloud database. Clinical, demographic, socioeconomic, psychological, metabolic, epigenetic and genotypic variables will be evaluated. The data resulting from this study will be useful to guide specific public strategies for primary and secondary prevention of metabolic and reproductive comorbidities in the PCOS population of Brazil.Ethics and dissemination The study protocol was approved by each local Research Ethics Committee. Written informed consent will be obtained from each participant. During data collection, analysis and publication, care will be taken to ensure confidentiality of participant information. Study results will be published in peer-reviewed journals and disseminated at international conferences. This research protocol was registered with the Research Ethics Committee of HCPA, through Plataforma Brasil.Trial registration number CAAE 18082413.9.1001.5327 |
| format | Article |
| id | doaj-art-0ee9e242c4384891baaa51d5b2a99072 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0ee9e242c4384891baaa51d5b2a990722025-08-20T02:37:50ZengBMJ Publishing GroupBMJ Open2044-60552019-10-0191010.1136/bmjopen-2019-029191Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control studyPoli Mara Spritzer0Lucas B Marchesan1Betânia R Santos2Felipe V Cureau3Karen Oppermann4Rosana Maria dos Reis5Rui A Ferriani6Rita Weiss7Ricardo Meirelles8Ana Lucia Candido9Fernando M Reis10Ana Luiza L. RochaEdmund C Baracat11Gustavo AR MacielGustavo Mafaldo SoaresHélio Haddad FilhoIvanice GemelliJose M Soares JuniorRamon B RamosSebastião F de MedeirosTécia Maria de Oliveira2 Gynecological Endocrinology Unit, Endocrine Division, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil1 Department of Physiology and Postgraduate Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil3 Postgraduate Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil3 Postgraduate Program in Medical Sciences: Endocrinology, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil4 Department of Gynecology and Obstetrics, Universidade de Passo Fundo, Passo Fundo, Brazil5 Department of Gynecology and Obstetrics Ribeirao Preto, Universidade de Sao Paulo Campus de Ribeirao Preto, Ribeirao Preto, Brazil5 Department of Gynecology and Obstetrics Ribeirao Preto, Universidade de Sao Paulo Campus de Ribeirao Preto, Ribeirao Preto, Brazil6 Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil6 Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, Brazil7 Department of Gynecology and Obstetrics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil7 Department of Gynecology and Obstetrics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil2 Disciplina de Ginecologia do Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, BrazilIntroduction Brazil is a large country, with a population of mixed ethnic background and broad variation in dietary and physical activity traits across its five main regions. Because data on Brazilian women with polycystic ovary syndrome (PCOS) are still scarce, a nation-wide collaborative study was designed to determine the prevalence of metabolic and reproductive abnormalities and the presence of anxiety and depression in Brazilian women with PCOS. In addition, the study aims at describing how these characteristics are distributed across PCOS phenotypes and at detecting associations with regional demographic and lifestyle aspects, genetic variants, and epigenetic markers.Methods and analysis The Brazilian PCOS study is being conducted in the outpatient clinics of eight university hospitals within the public healthcare network (Unified Health System) across the country. Additional centres will be included following completion of the research ethics approval process. The sample includes women with PCOS according to Rotterdam criteria at inclusion in the study and a control group of healthy women matched by age, socioeconomic status and geographical region. Data will be collected in each centre and incorporated into a unified cloud database. Clinical, demographic, socioeconomic, psychological, metabolic, epigenetic and genotypic variables will be evaluated. The data resulting from this study will be useful to guide specific public strategies for primary and secondary prevention of metabolic and reproductive comorbidities in the PCOS population of Brazil.Ethics and dissemination The study protocol was approved by each local Research Ethics Committee. Written informed consent will be obtained from each participant. During data collection, analysis and publication, care will be taken to ensure confidentiality of participant information. Study results will be published in peer-reviewed journals and disseminated at international conferences. This research protocol was registered with the Research Ethics Committee of HCPA, through Plataforma Brasil.Trial registration number CAAE 18082413.9.1001.5327https://bmjopen.bmj.com/content/9/10/e029191.full |
| spellingShingle | Poli Mara Spritzer Lucas B Marchesan Betânia R Santos Felipe V Cureau Karen Oppermann Rosana Maria dos Reis Rui A Ferriani Rita Weiss Ricardo Meirelles Ana Lucia Candido Fernando M Reis Ana Luiza L. Rocha Edmund C Baracat Gustavo AR Maciel Gustavo Mafaldo Soares Hélio Haddad Filho Ivanice Gemelli Jose M Soares Junior Ramon B Ramos Sebastião F de Medeiros Técia Maria de Oliveira Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study BMJ Open |
| title | Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study |
| title_full | Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study |
| title_fullStr | Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study |
| title_full_unstemmed | Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study |
| title_short | Prevalence and characteristics of polycystic ovary syndrome in Brazilian women: protocol for a nation-wide case–control study |
| title_sort | prevalence and characteristics of polycystic ovary syndrome in brazilian women protocol for a nation wide case control study |
| url | https://bmjopen.bmj.com/content/9/10/e029191.full |
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