Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis
Neonatal sepsis is a significant health issue associated with high mortality. Immune responses associated with neonatal sepsis, such as proinflammatory cytokine production, are believed to play a central role in the pathogenesis of this disease. In the present study, serum levels of the proinflammat...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/8601063 |
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| author | Kh. S. Khaertynov S. V. Boichuk S. F. Khaiboullina V. A. Anokhin A. A. Andreeva V. C. Lombardi M. A. Satrutdinov E. A. Agafonova A. A. Rizvanov |
| author_facet | Kh. S. Khaertynov S. V. Boichuk S. F. Khaiboullina V. A. Anokhin A. A. Andreeva V. C. Lombardi M. A. Satrutdinov E. A. Agafonova A. A. Rizvanov |
| author_sort | Kh. S. Khaertynov |
| collection | DOAJ |
| description | Neonatal sepsis is a significant health issue associated with high mortality. Immune responses associated with neonatal sepsis, such as proinflammatory cytokine production, are believed to play a central role in the pathogenesis of this disease. In the present study, serum levels of the proinflammatory cytokines TNF-α, IL1-β, and IL-6 and the anti-inflammatory cytokines IL-4 and IL-10 were evaluated for 25 subjects with neonatal sepsis. We observed that subjects with late onset of sepsis (LOS), as well as those with early onset of sepsis (EOS), had a substantial increase in serum TNF-α. In contrast to EOS, subjects with LOS demonstrated a significant increase in serum levels IL-6 and IL-10. Additionally, we observed a significant difference in cytokine profiles between acute and postacute cases of neonatal sepsis. For instance, the level of proinflammatory cytokines, such as TNF-α and IL-6, was elevated in the acute phase, whereas the production of anti-inflammatory cytokines, such as IL-10, became substantially upregulated during the postacute phase. Additionally, no correlation was observed between cytokine levels and CRP levels or lymphocyte counts. Thus, in contrast to CRP levels and lymphocyte counts, examination of the cytokine profile can provide valuable information when determining the most effective therapy for treating neonatal sepsis. This information may be useful to physicians when determining if anti-inflammatory or immune stimulatory therapy is warranted. |
| format | Article |
| id | doaj-art-0ee8f4b8cf584241a061ca2be1216418 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0ee8f4b8cf584241a061ca2be12164182025-08-20T02:02:26ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/86010638601063Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal SepsisKh. S. Khaertynov0S. V. Boichuk1S. F. Khaiboullina2V. A. Anokhin3A. A. Andreeva4V. C. Lombardi5M. A. Satrutdinov6E. A. Agafonova7A. A. Rizvanov8Kazan State Medical University, Kazan, RussiaKazan State Medical University, Kazan, RussiaKazan Federal University, Kazan, RussiaKazan State Medical University, Kazan, RussiaRepublic Children’s Clinical Hospital, Kazan, RussiaKazan Federal University, Kazan, RussiaRepublic Children’s Clinical Hospital, Kazan, RussiaRepublic Children’s Clinical Hospital, Kazan, RussiaKazan Federal University, Kazan, RussiaNeonatal sepsis is a significant health issue associated with high mortality. Immune responses associated with neonatal sepsis, such as proinflammatory cytokine production, are believed to play a central role in the pathogenesis of this disease. In the present study, serum levels of the proinflammatory cytokines TNF-α, IL1-β, and IL-6 and the anti-inflammatory cytokines IL-4 and IL-10 were evaluated for 25 subjects with neonatal sepsis. We observed that subjects with late onset of sepsis (LOS), as well as those with early onset of sepsis (EOS), had a substantial increase in serum TNF-α. In contrast to EOS, subjects with LOS demonstrated a significant increase in serum levels IL-6 and IL-10. Additionally, we observed a significant difference in cytokine profiles between acute and postacute cases of neonatal sepsis. For instance, the level of proinflammatory cytokines, such as TNF-α and IL-6, was elevated in the acute phase, whereas the production of anti-inflammatory cytokines, such as IL-10, became substantially upregulated during the postacute phase. Additionally, no correlation was observed between cytokine levels and CRP levels or lymphocyte counts. Thus, in contrast to CRP levels and lymphocyte counts, examination of the cytokine profile can provide valuable information when determining the most effective therapy for treating neonatal sepsis. This information may be useful to physicians when determining if anti-inflammatory or immune stimulatory therapy is warranted.http://dx.doi.org/10.1155/2017/8601063 |
| spellingShingle | Kh. S. Khaertynov S. V. Boichuk S. F. Khaiboullina V. A. Anokhin A. A. Andreeva V. C. Lombardi M. A. Satrutdinov E. A. Agafonova A. A. Rizvanov Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis Journal of Immunology Research |
| title | Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis |
| title_full | Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis |
| title_fullStr | Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis |
| title_full_unstemmed | Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis |
| title_short | Comparative Assessment of Cytokine Pattern in Early and Late Onset of Neonatal Sepsis |
| title_sort | comparative assessment of cytokine pattern in early and late onset of neonatal sepsis |
| url | http://dx.doi.org/10.1155/2017/8601063 |
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