Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Vincamine induces cytoprotective autophagy via regulation of ampk/mtor signaling pathway in gentamicin-induced hepatotoxicity and nephrotoxicity in rats

Abstract Gentamicin (GET), a widely utilized aminoglycoside antibiotic for severe bacterial infections, is associated with significant hepatorenal toxicity. These adverse effects are frequently exacerbated by GET-induced oxidative stress and inflammation. This study aimed to evaluate the potential p...

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Bibliographic Details
Main Authors: Alaa Abouelhamd, Nourhan Elpry Mahmoud Shehata, Sara Mohamed Naguib Abdel-Hafez, Dalia H. Abu-Baih
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Vincamine
Gentamicin
Nephrotoxicity
Hepatotoxicity
Autophagy.
Online Access:https://doi.org/10.1038/s41598-025-06355-5
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