Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review
The proteasomal system of protein degradation is crucial for various cellular processes, including transduction of signals and differentiation of cells. Proteasome activity rises after various traumatic stressors such as hyperoxia, radiation, or oxidative damage. Removal of damaged proteins is essen...
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MDPI AG
2025-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/15/3/413 |
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| author | Marzena Tylicka Ewa Matuszczak Joanna Kamińska Beata Modzelewska Olga Martyna Koper-Lenkiewicz |
| author_facet | Marzena Tylicka Ewa Matuszczak Joanna Kamińska Beata Modzelewska Olga Martyna Koper-Lenkiewicz |
| author_sort | Marzena Tylicka |
| collection | DOAJ |
| description | The proteasomal system of protein degradation is crucial for various cellular processes, including transduction of signals and differentiation of cells. Proteasome activity rises after various traumatic stressors such as hyperoxia, radiation, or oxidative damage. Removal of damaged proteins is essential to provide the necessary conditions for cell repair. Several studies report the activation of the proteasomal degradation system after thermal injury, CNS injury, abdominal trauma, ischemia-reperfusion injury, and possible clinical implications of the use of proteasome inhibitors. It is important to highlight the distinct and crucial roles of UCHL1, 26S, and 20S proteasome subunits as biomarkers. UCHL1 appears to be particularly relevant for identifying brain and neuronal damage and in advancing the diagnosis and prognosis of traumatic brain injury (TBI) and other neurological conditions. Meanwhile, the 26S and 20S proteasomes may serve as markers for peripheral tissue damage. This differentiation enhances our understanding and ability to target specific types of tissue damage in clinical settings. |
| format | Article |
| id | doaj-art-0ee6e0e745994b5081efdd7151cd2798 |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-0ee6e0e745994b5081efdd7151cd27982025-08-20T02:11:24ZengMDPI AGLife2075-17292025-03-0115341310.3390/life15030413Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short ReviewMarzena Tylicka0Ewa Matuszczak1Joanna Kamińska2Beata Modzelewska3Olga Martyna Koper-Lenkiewicz4Department of Biophysics, Medical University of Bialystok, Mickiewicza 2a, 15-222 Bialystok, PolandDepartment of Pediatric Surgery, Medical University of Bialystok, Waszyngtona 17, 15-274 Bialystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandDepartment of Biophysics, Medical University of Bialystok, Mickiewicza 2a, 15-222 Bialystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A, 15-269 Bialystok, PolandThe proteasomal system of protein degradation is crucial for various cellular processes, including transduction of signals and differentiation of cells. Proteasome activity rises after various traumatic stressors such as hyperoxia, radiation, or oxidative damage. Removal of damaged proteins is essential to provide the necessary conditions for cell repair. Several studies report the activation of the proteasomal degradation system after thermal injury, CNS injury, abdominal trauma, ischemia-reperfusion injury, and possible clinical implications of the use of proteasome inhibitors. It is important to highlight the distinct and crucial roles of UCHL1, 26S, and 20S proteasome subunits as biomarkers. UCHL1 appears to be particularly relevant for identifying brain and neuronal damage and in advancing the diagnosis and prognosis of traumatic brain injury (TBI) and other neurological conditions. Meanwhile, the 26S and 20S proteasomes may serve as markers for peripheral tissue damage. This differentiation enhances our understanding and ability to target specific types of tissue damage in clinical settings.https://www.mdpi.com/2075-1729/15/3/413proteasomeubiquitin-proteasome systemUCHL1traumainjuryhead trauma |
| spellingShingle | Marzena Tylicka Ewa Matuszczak Joanna Kamińska Beata Modzelewska Olga Martyna Koper-Lenkiewicz Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review Life proteasome ubiquitin-proteasome system UCHL1 trauma injury head trauma |
| title | Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review |
| title_full | Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review |
| title_fullStr | Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review |
| title_full_unstemmed | Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review |
| title_short | Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review |
| title_sort | proteasomes and ubiquitin c terminal hydrolase l1 as biomarkers of tissue damage and inflammatory response to different types of injury a short review |
| topic | proteasome ubiquitin-proteasome system UCHL1 trauma injury head trauma |
| url | https://www.mdpi.com/2075-1729/15/3/413 |
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