Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface
The agonist–antagonist myoneural interface (AMI), a surgical method to reinnervate physiologically-relevant proprioceptive feedback for control of limb prostheses, has demonstrated the ability to provide natural afferent sensations for limb amputees when actuating their prostheses. Following AMI sur...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-09-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/11/9/904 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850258974514872320 |
|---|---|
| author | Jianping Huang Ping Wang Wei Wang Jingjing Wei Lin Yang Zhiyuan Liu Guanglin Li |
| author_facet | Jianping Huang Ping Wang Wei Wang Jingjing Wei Lin Yang Zhiyuan Liu Guanglin Li |
| author_sort | Jianping Huang |
| collection | DOAJ |
| description | The agonist–antagonist myoneural interface (AMI), a surgical method to reinnervate physiologically-relevant proprioceptive feedback for control of limb prostheses, has demonstrated the ability to provide natural afferent sensations for limb amputees when actuating their prostheses. Following AMI surgery, one potential challenge is atrophy of the disused muscles, which would weaken the reinnervation efficacy of AMI. It is well known that electrical muscle stimulus (EMS) can reduce muscle atrophy. In this study, we conducted an animal investigation to explore whether the EMS can significantly improve the electrophysiological performance of AMI. AMI surgery was performed in 14 rats, in which the distal tendons of bilateral solei donors were connected and positioned on the surface of the left biceps femoris. Subsequently, the left tibial nerve and the common peroneus nerve were sutured onto the ends of the connected donor solei. Two stimulation electrodes were affixed onto the ends of the donor solei for EMS delivery. The AMI rats were randomly divided into two groups. One group received the EMS treatment (designated as EMS_on) regularly for eight weeks and another received no EMS (designated as EMS_off). Two physiological parameters, nerve conduction velocity (NCV) and motor unit number, were derived from the electrically evoked compound action potential (CAP) signals to assess the electrophysiological performance of AMI. Our experimental results demonstrated that the reinnervated muscles of the EMS_on group generated higher CAP signals in comparison to the EMS_off group. Both NCV and motor unit number were significantly elevated in the EMS_on group. Moreover, the EMS_on group displayed statistically higher CAP signals on the indirectly activated proprioceptive afferents than the EMS_off group. These findings suggested that EMS treatment would be promising in enhancing the electrophysiological performance and facilitating the reinnervation process of AMI. |
| format | Article |
| id | doaj-art-0ee4bffe08dc4491a50026e7b42a97ef |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-0ee4bffe08dc4491a50026e7b42a97ef2025-08-20T01:56:00ZengMDPI AGBioengineering2306-53542024-09-0111990410.3390/bioengineering11090904Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural InterfaceJianping Huang0Ping Wang1Wei Wang2Jingjing Wei3Lin Yang4Zhiyuan Liu5Guanglin Li6Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaBiomedical Sensing Engineering and Technology Research Center, Shandong University, Jinan 250000, ChinaShenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaShenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, Shenzhen 518055, ChinaThe agonist–antagonist myoneural interface (AMI), a surgical method to reinnervate physiologically-relevant proprioceptive feedback for control of limb prostheses, has demonstrated the ability to provide natural afferent sensations for limb amputees when actuating their prostheses. Following AMI surgery, one potential challenge is atrophy of the disused muscles, which would weaken the reinnervation efficacy of AMI. It is well known that electrical muscle stimulus (EMS) can reduce muscle atrophy. In this study, we conducted an animal investigation to explore whether the EMS can significantly improve the electrophysiological performance of AMI. AMI surgery was performed in 14 rats, in which the distal tendons of bilateral solei donors were connected and positioned on the surface of the left biceps femoris. Subsequently, the left tibial nerve and the common peroneus nerve were sutured onto the ends of the connected donor solei. Two stimulation electrodes were affixed onto the ends of the donor solei for EMS delivery. The AMI rats were randomly divided into two groups. One group received the EMS treatment (designated as EMS_on) regularly for eight weeks and another received no EMS (designated as EMS_off). Two physiological parameters, nerve conduction velocity (NCV) and motor unit number, were derived from the electrically evoked compound action potential (CAP) signals to assess the electrophysiological performance of AMI. Our experimental results demonstrated that the reinnervated muscles of the EMS_on group generated higher CAP signals in comparison to the EMS_off group. Both NCV and motor unit number were significantly elevated in the EMS_on group. Moreover, the EMS_on group displayed statistically higher CAP signals on the indirectly activated proprioceptive afferents than the EMS_off group. These findings suggested that EMS treatment would be promising in enhancing the electrophysiological performance and facilitating the reinnervation process of AMI.https://www.mdpi.com/2306-5354/11/9/904agonist–antagonist myoneural interfaceelectrical muscle stimulationmuscle reinnervationproprioceptionelectromyographtargeted muscle reinnervation |
| spellingShingle | Jianping Huang Ping Wang Wei Wang Jingjing Wei Lin Yang Zhiyuan Liu Guanglin Li Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface Bioengineering agonist–antagonist myoneural interface electrical muscle stimulation muscle reinnervation proprioception electromyograph targeted muscle reinnervation |
| title | Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface |
| title_full | Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface |
| title_fullStr | Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface |
| title_full_unstemmed | Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface |
| title_short | Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface |
| title_sort | using electrical muscle stimulation to enhance electrophysiological performance of agonist antagonist myoneural interface |
| topic | agonist–antagonist myoneural interface electrical muscle stimulation muscle reinnervation proprioception electromyograph targeted muscle reinnervation |
| url | https://www.mdpi.com/2306-5354/11/9/904 |
| work_keys_str_mv | AT jianpinghuang usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT pingwang usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT weiwang usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT jingjingwei usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT linyang usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT zhiyuanliu usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface AT guanglinli usingelectricalmusclestimulationtoenhanceelectrophysiologicalperformanceofagonistantagonistmyoneuralinterface |