Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer
Abstract The poliovirus receptor-related immunoglobulin domain-containing protein (PVRIG) is a recently identified immune checkpoint receptor predominantly expressed on natural killer and CD8 + T cells. This study investigated the role of PVRIG in the tumor immune microenvironment and its prognostic...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-89308-2 |
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| author | Peng Ma Ruichen Zhang Weili Sun |
| author_facet | Peng Ma Ruichen Zhang Weili Sun |
| author_sort | Peng Ma |
| collection | DOAJ |
| description | Abstract The poliovirus receptor-related immunoglobulin domain-containing protein (PVRIG) is a recently identified immune checkpoint receptor predominantly expressed on natural killer and CD8 + T cells. This study investigated the role of PVRIG in the tumor immune microenvironment and its prognostic significance across various cancers. Using bioinformatics analyses, the study revealed that PVRIG expression is associated with immune cell infiltration, immune modulator gene expression, clinical outcomes, CD8 + T cell functionality, and responses to immunotherapies and targeted treatments. Additionally, in vitro and in vivo experiments confirmed that PVRIG plays a critical role in regulating CD8 + T cell functionality. These findings suggest that PVRIG could serve as a biomarker for prognosis and immune infiltration, as well as a promising target for novel cancer immunotherapies. |
| format | Article |
| id | doaj-art-0ee2ef9c08b448169440b7c71bfc9c6f |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0ee2ef9c08b448169440b7c71bfc9c6f2025-08-20T03:10:09ZengNature PortfolioScientific Reports2045-23222025-04-0115111810.1038/s41598-025-89308-2Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancerPeng Ma0Ruichen Zhang1Weili Sun2Department of Gastroenterology, Jingzhou Hospital Affiliated to Yangtze UniversityDepartment of Electronic Information Engineering, Hubei University of TechnologyDivision of Experimental Medicine, McGill UniversityAbstract The poliovirus receptor-related immunoglobulin domain-containing protein (PVRIG) is a recently identified immune checkpoint receptor predominantly expressed on natural killer and CD8 + T cells. This study investigated the role of PVRIG in the tumor immune microenvironment and its prognostic significance across various cancers. Using bioinformatics analyses, the study revealed that PVRIG expression is associated with immune cell infiltration, immune modulator gene expression, clinical outcomes, CD8 + T cell functionality, and responses to immunotherapies and targeted treatments. Additionally, in vitro and in vivo experiments confirmed that PVRIG plays a critical role in regulating CD8 + T cell functionality. These findings suggest that PVRIG could serve as a biomarker for prognosis and immune infiltration, as well as a promising target for novel cancer immunotherapies.https://doi.org/10.1038/s41598-025-89308-2PVRIGPrognosisImmune checkpointCancerImmunotherapy |
| spellingShingle | Peng Ma Ruichen Zhang Weili Sun Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer Scientific Reports PVRIG Prognosis Immune checkpoint Cancer Immunotherapy |
| title | Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer |
| title_full | Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer |
| title_fullStr | Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer |
| title_full_unstemmed | Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer |
| title_short | Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer |
| title_sort | integrating bioinformatics with experimental validation unveils immunological and prognostic significance of pvrig in pan cancer |
| topic | PVRIG Prognosis Immune checkpoint Cancer Immunotherapy |
| url | https://doi.org/10.1038/s41598-025-89308-2 |
| work_keys_str_mv | AT pengma integratingbioinformaticswithexperimentalvalidationunveilsimmunologicalandprognosticsignificanceofpvriginpancancer AT ruichenzhang integratingbioinformaticswithexperimentalvalidationunveilsimmunologicalandprognosticsignificanceofpvriginpancancer AT weilisun integratingbioinformaticswithexperimentalvalidationunveilsimmunologicalandprognosticsignificanceofpvriginpancancer |