Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid
Objective: Keloids are characterized by abnormal activation of fibroblasts and excessive collagen deposition. Keloids are notoriously difficult to treat effectively due to their high recurrence rate after therapy. Our study explored the use of the punch technique in conjunction with photodynamic the...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-10-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024003855 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850282219535335424 |
|---|---|
| author | Xiaomei Cui Jie Ji Lipan Fan Xingbao Luan Litian Zhao Zhangjun Ding Xiaodong Chen Dan Luo |
| author_facet | Xiaomei Cui Jie Ji Lipan Fan Xingbao Luan Litian Zhao Zhangjun Ding Xiaodong Chen Dan Luo |
| author_sort | Xiaomei Cui |
| collection | DOAJ |
| description | Objective: Keloids are characterized by abnormal activation of fibroblasts and excessive collagen deposition. Keloids are notoriously difficult to treat effectively due to their high recurrence rate after therapy. Our study explored the use of the punch technique in conjunction with photodynamic therapy, a novel approach that may swiftly reduce keloid volume, promote collagen remodeling, mitigate inflammation and enhance the wound healing process. Methods: In our study, we conducted a retrospective analysis of 47 keloid patients who were treated with cross-punch technique combined with photodynamic therapy (punch+PDT group), compared them with a control group of 42 patients who received cross-punch therapy alone (punch group). The visual Analog Scale (VAS) scoring system, the Dermatology Life Quality Index (DLQI) questionnaire and the subjective scoring of patients were implemented to assess the improvement rate at baseline (month 0) and 12-month follow-up (month 12). Results: The results demonstrated significant enhancements in both VAS scores and DLQI scores on month 12 when compared with those on month 0. Notably, the subjective scoring indicated a marked difference, with 93.62 % of patients in the punch+PDT group and 59.52 % in the punch group reporting good or excellent improvement. Conclusion: Patients in the punch+PDT group had a significant improvement rate than those in the punch group. |
| format | Article |
| id | doaj-art-0ee0fbf3d8f94348a5d40bde204a113a |
| institution | OA Journals |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-0ee0fbf3d8f94348a5d40bde204a113a2025-08-20T01:48:03ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-10-014910434810.1016/j.pdpdt.2024.104348Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloidXiaomei Cui0Jie Ji1Lipan Fan2Xingbao Luan3Litian Zhao4Zhangjun Ding5Xiaodong Chen6Dan Luo7Department of Dermatology, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR China; Department of Medical Cosmetology, Department of Dermatology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, PR ChinaDepartment of Dermatology, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR ChinaDepartment of Dermatology, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR ChinaDepartment of Dermatology, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR ChinaFuyang Medical School, Fuyang normal university, Fuyang 236000, Anhui Province, PR ChinaDepartment of Dermatology, Dongtai People's Hospital, Yancheng 224200, Jiangsu Province, PR ChinaDepartment of Medical Cosmetology, Department of Dermatology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, PR China; Corresponding author at: Department of Dermatology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu Province, 226001, PR China.Department of Dermatology, Jiangsu Provincial People's Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, PR China; Corresponding author at: Nanjing Medical University, Department of Dermatology, Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, PR China.Objective: Keloids are characterized by abnormal activation of fibroblasts and excessive collagen deposition. Keloids are notoriously difficult to treat effectively due to their high recurrence rate after therapy. Our study explored the use of the punch technique in conjunction with photodynamic therapy, a novel approach that may swiftly reduce keloid volume, promote collagen remodeling, mitigate inflammation and enhance the wound healing process. Methods: In our study, we conducted a retrospective analysis of 47 keloid patients who were treated with cross-punch technique combined with photodynamic therapy (punch+PDT group), compared them with a control group of 42 patients who received cross-punch therapy alone (punch group). The visual Analog Scale (VAS) scoring system, the Dermatology Life Quality Index (DLQI) questionnaire and the subjective scoring of patients were implemented to assess the improvement rate at baseline (month 0) and 12-month follow-up (month 12). Results: The results demonstrated significant enhancements in both VAS scores and DLQI scores on month 12 when compared with those on month 0. Notably, the subjective scoring indicated a marked difference, with 93.62 % of patients in the punch+PDT group and 59.52 % in the punch group reporting good or excellent improvement. Conclusion: Patients in the punch+PDT group had a significant improvement rate than those in the punch group.http://www.sciencedirect.com/science/article/pii/S1572100024003855KeloidPhotodynamic therapySurgery |
| spellingShingle | Xiaomei Cui Jie Ji Lipan Fan Xingbao Luan Litian Zhao Zhangjun Ding Xiaodong Chen Dan Luo Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid Photodiagnosis and Photodynamic Therapy Keloid Photodynamic therapy Surgery |
| title | Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid |
| title_full | Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid |
| title_fullStr | Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid |
| title_full_unstemmed | Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid |
| title_short | Efficacy of photodynamic therapy combined with cross-punch technique for the treatment of keloid |
| title_sort | efficacy of photodynamic therapy combined with cross punch technique for the treatment of keloid |
| topic | Keloid Photodynamic therapy Surgery |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024003855 |
| work_keys_str_mv | AT xiaomeicui efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT jieji efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT lipanfan efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT xingbaoluan efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT litianzhao efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT zhangjunding efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT xiaodongchen efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid AT danluo efficacyofphotodynamictherapycombinedwithcrosspunchtechniqueforthetreatmentofkeloid |