The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective
Asthma, the most common chronic respiratory disease in children, affects numerous people worldwide. Accumulating evidence suggests that exposure to high levels of particulate matter (PM), either acutely or chronically, is associated with the exacerbation and incidence of pediatric asthma. However, t...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8254909 |
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| _version_ | 1832561129356787712 |
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| author | Xuchen Xu Jianing Zhang Xin Yang Yuanyuan Zhang Zhimin Chen |
| author_facet | Xuchen Xu Jianing Zhang Xin Yang Yuanyuan Zhang Zhimin Chen |
| author_sort | Xuchen Xu |
| collection | DOAJ |
| description | Asthma, the most common chronic respiratory disease in children, affects numerous people worldwide. Accumulating evidence suggests that exposure to high levels of particulate matter (PM), either acutely or chronically, is associated with the exacerbation and incidence of pediatric asthma. However, the detailed pathogenic mechanisms by which PM contributes to the incidence of asthma remain largely unknown. In this short review, we summarize studies of relationships between PM and pediatric asthma and recent advances on the fundamental mechanisms of PM-related asthma, with emphases on cell death regulation and immune system responses. We further discuss the inadequacy of current studies and give a perspective on the prevention strategies for pediatric asthma. |
| format | Article |
| id | doaj-art-0ee04dd6b76f4effacc37773a53b40a4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0ee04dd6b76f4effacc37773a53b40a42025-02-03T01:25:49ZengWileyJournal of Immunology Research2314-88612314-71562020-01-01202010.1155/2020/82549098254909The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and PerspectiveXuchen Xu0Jianing Zhang1Xin Yang2Yuanyuan Zhang3Zhimin Chen4Department of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, ChinaDepartment of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Pulmonology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaAsthma, the most common chronic respiratory disease in children, affects numerous people worldwide. Accumulating evidence suggests that exposure to high levels of particulate matter (PM), either acutely or chronically, is associated with the exacerbation and incidence of pediatric asthma. However, the detailed pathogenic mechanisms by which PM contributes to the incidence of asthma remain largely unknown. In this short review, we summarize studies of relationships between PM and pediatric asthma and recent advances on the fundamental mechanisms of PM-related asthma, with emphases on cell death regulation and immune system responses. We further discuss the inadequacy of current studies and give a perspective on the prevention strategies for pediatric asthma.http://dx.doi.org/10.1155/2020/8254909 |
| spellingShingle | Xuchen Xu Jianing Zhang Xin Yang Yuanyuan Zhang Zhimin Chen The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective Journal of Immunology Research |
| title | The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective |
| title_full | The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective |
| title_fullStr | The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective |
| title_full_unstemmed | The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective |
| title_short | The Role and Potential Pathogenic Mechanism of Particulate Matter in Childhood Asthma: A Review and Perspective |
| title_sort | role and potential pathogenic mechanism of particulate matter in childhood asthma a review and perspective |
| url | http://dx.doi.org/10.1155/2020/8254909 |
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