Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection

Hamsters immunized with formalin-inactivated SARS-CoV-2 develop accelerated lung histopathological lesions and Th2-biased response following infection

Abstract One of the concerns regarding vaccine safety during the COVID-19 pandemic was the potential manifestation of vaccine-associated enhancement of disease (VAED) upon SARS-CoV-2 infection. To investigate the suitability of the Syrian hamster model to test for VAED, we immunized animals with an...

Full description

Saved in:
Bibliographic Details
Main Authors: Rineke de Jong, Sandra Vreman, Katrin E. Wiese, Nora M. Gerhards, Kevin R. Bewley, Yper Hall, Francisco Javier Salguero, Miles Carroll, Rik L. de Swart, Jose L. Gonzales, Nadia Oreshkova
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01160-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items