Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury

Zileuton protects against arachidonic acid/5-lipoxygenase/leukotriene axis-mediated neuroinflammation in experimental traumatic brain injury

IntroductionTraumatic brain injury (TBI) is a leading cause of death and disability globally. Several studies have shown that 5-lipoxygenase (5-LOX) inhibition reduces leukotriene (LT) release and the inflammatory response, attenuating the development of respiratory diseases, myocardial infarction,...

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Bibliographic Details
Main Authors: Xiaofeng Xu, Yan Wang, Xiaomei Li, Yang Yang, Dianxu Yang, Wenqi Tang, Jin Lu, Fang Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
zileuton
5-lipoxygenase
leukotriene
microglial cells
neuroinflammation
traumatic brain injury
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1516836/full
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