A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice
This study investigated the anti-anxiety/anti-depression potential of a formula containing red pomegranate fruit extract (RPFE; 40%, m/m), Lactobacillus rhamnosus (JB-1) (34%, m/m), magnesium gluconate (25%, m/m) and vanillin (1%, m/m). The RPFE formula (dose: 2.0, 1.5 or 1.0 mg/g day) reversed beha...
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| Language: | English |
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Tsinghua University Press
2021-05-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221345302100029X |
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| author | Xiping Zhu Dongxiao Sun-Waterhouse Chun Cui |
| author_facet | Xiping Zhu Dongxiao Sun-Waterhouse Chun Cui |
| author_sort | Xiping Zhu |
| collection | DOAJ |
| description | This study investigated the anti-anxiety/anti-depression potential of a formula containing red pomegranate fruit extract (RPFE; 40%, m/m), Lactobacillus rhamnosus (JB-1) (34%, m/m), magnesium gluconate (25%, m/m) and vanillin (1%, m/m). The RPFE formula (dose: 2.0, 1.5 or 1.0 mg/g day) reversed behavioral dysfunctions and body weight gain induced by chronic restraint stress combined with corticosterone injection in C57BL/6 male mice. The RPFE formula exhibited the abilities to normalize the levels of serum inflammatory cytokines (NF-κB, TNF-α, IL-6, IL-1β and IFN-γ) and malondialdehyde (MDA), and activities of superoxide dismutase (SOD), catalase (CAT) and nitric oxide synthase (NOS), as well as relieve the injury of hippocampal neurons. The serotonin (5-HT) levels in hippocampus were increasingly enhanced, which might be mediated by reducing the activity of indoleamine-2,3-dioxygenase (IDO) and increasing the activity of tryptophan hydroxylase (TPH). Thus, the neuroprotective and ameliorating effects on anxiety/depression-like behaviors resulting from the RPFE formula ingestion were possibly related to serotonergic activation, which might be mediated via anti-inflammatory and anti-oxidant actions. |
| format | Article |
| id | doaj-art-0ed9a6e8b4564850a0cffde5f64d8d3d |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-0ed9a6e8b4564850a0cffde5f64d8d3d2025-02-03T04:01:26ZengTsinghua University PressFood Science and Human Wellness2213-45302021-05-01103289296A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male miceXiping Zhu0Dongxiao Sun-Waterhouse1Chun Cui2College of Food Science and Engineering, South China University of Technology, Guangzhou 510000, Guangdong, China; College of Biological and Food Engineering, Anhui Polytechnic University, Wuhu 241000, Anhui, ChinaCollege of Food Science and Engineering, South China University of Technology, Guangzhou 510000, Guangdong, ChinaCollege of Food Science and Engineering, South China University of Technology, Guangzhou 510000, Guangdong, China; Guangdong Weiwei Biotechnology Co., LTD., Guangzhou 510640, China; Corresponding author. College of Food Science and Technology, South China University of Technology, Guangzhou 510640, Guangdong, China. Tel.:/fax: +86 20 87114954.This study investigated the anti-anxiety/anti-depression potential of a formula containing red pomegranate fruit extract (RPFE; 40%, m/m), Lactobacillus rhamnosus (JB-1) (34%, m/m), magnesium gluconate (25%, m/m) and vanillin (1%, m/m). The RPFE formula (dose: 2.0, 1.5 or 1.0 mg/g day) reversed behavioral dysfunctions and body weight gain induced by chronic restraint stress combined with corticosterone injection in C57BL/6 male mice. The RPFE formula exhibited the abilities to normalize the levels of serum inflammatory cytokines (NF-κB, TNF-α, IL-6, IL-1β and IFN-γ) and malondialdehyde (MDA), and activities of superoxide dismutase (SOD), catalase (CAT) and nitric oxide synthase (NOS), as well as relieve the injury of hippocampal neurons. The serotonin (5-HT) levels in hippocampus were increasingly enhanced, which might be mediated by reducing the activity of indoleamine-2,3-dioxygenase (IDO) and increasing the activity of tryptophan hydroxylase (TPH). Thus, the neuroprotective and ameliorating effects on anxiety/depression-like behaviors resulting from the RPFE formula ingestion were possibly related to serotonergic activation, which might be mediated via anti-inflammatory and anti-oxidant actions.http://www.sciencedirect.com/science/article/pii/S221345302100029XBehavioral testsRed pomegranate fruit extract5-HTAnti-inflammatoryAnxiety/depression |
| spellingShingle | Xiping Zhu Dongxiao Sun-Waterhouse Chun Cui A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice Food Science and Human Wellness Behavioral tests Red pomegranate fruit extract 5-HT Anti-inflammatory Anxiety/depression |
| title | A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice |
| title_full | A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice |
| title_fullStr | A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice |
| title_full_unstemmed | A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice |
| title_short | A red pomegranate fruit extract-based formula ameliorates anxiety/depression-like behaviors via enhancing serotonin (5-HT) synthesis in C57BL/6 male mice |
| title_sort | red pomegranate fruit extract based formula ameliorates anxiety depression like behaviors via enhancing serotonin 5 ht synthesis in c57bl 6 male mice |
| topic | Behavioral tests Red pomegranate fruit extract 5-HT Anti-inflammatory Anxiety/depression |
| url | http://www.sciencedirect.com/science/article/pii/S221345302100029X |
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