MiRNAs in cancer therapy: focusing on their bi-directional roles
Abstract MicroRNA (miRNA) dysregulation is causal in most, if not all, cancers. They silence the gene’s expression by modulating messenger RNA (mRNA) through employing translational repression or degradation. MiRNA has the ability to target various genes, which involve various significant signaling...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-02-01
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| Series: | ExRNA |
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| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0005-1 |
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| author | Wei He Jinzhi Xu Zhen Huang Junfeng Zhang Lei Dong |
| author_facet | Wei He Jinzhi Xu Zhen Huang Junfeng Zhang Lei Dong |
| author_sort | Wei He |
| collection | DOAJ |
| description | Abstract MicroRNA (miRNA) dysregulation is causal in most, if not all, cancers. They silence the gene’s expression by modulating messenger RNA (mRNA) through employing translational repression or degradation. MiRNA has the ability to target various genes, which involve various significant signaling pathway in cancer cells, to control cancer development and progression. As a result, manipulating miRNA expression levels for cancer therapy seems an attractive and novel therapeutic approach. However, certain miRNAs, which possess the bi-directional roles, could promote cancer cells growth, but also enhance T-cell immunity. Therefore, miRNA-based therapy could also kill T cells and other lymphocytes, ultimately resulting in promoting cancer growth, which makes miRNA-based cancer therapy process with caution. In this view, we will focus on these miRNAs with the bi-directional roles, and discuss their potential effects to cancer therapy. Ultimately, identified and dissected the miRNAs crossing both T-cell-mediated anti-tumor immunity and tumor cell growth will prove vital for the design of more effective and safer strategies for cancer therapy. |
| format | Article |
| id | doaj-art-0ed6fbb841f043e181bd584848caea13 |
| institution | DOAJ |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-0ed6fbb841f043e181bd584848caea132025-08-20T02:54:58ZengELS Publishing (ELSP)ExRNA2398-00602019-02-01111610.1186/s41544-019-0005-1MiRNAs in cancer therapy: focusing on their bi-directional rolesWei He0Jinzhi Xu1Zhen Huang2Junfeng Zhang3Lei Dong4State Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences Nanjing UniversityAbstract MicroRNA (miRNA) dysregulation is causal in most, if not all, cancers. They silence the gene’s expression by modulating messenger RNA (mRNA) through employing translational repression or degradation. MiRNA has the ability to target various genes, which involve various significant signaling pathway in cancer cells, to control cancer development and progression. As a result, manipulating miRNA expression levels for cancer therapy seems an attractive and novel therapeutic approach. However, certain miRNAs, which possess the bi-directional roles, could promote cancer cells growth, but also enhance T-cell immunity. Therefore, miRNA-based therapy could also kill T cells and other lymphocytes, ultimately resulting in promoting cancer growth, which makes miRNA-based cancer therapy process with caution. In this view, we will focus on these miRNAs with the bi-directional roles, and discuss their potential effects to cancer therapy. Ultimately, identified and dissected the miRNAs crossing both T-cell-mediated anti-tumor immunity and tumor cell growth will prove vital for the design of more effective and safer strategies for cancer therapy.http://link.springer.com/article/10.1186/s41544-019-0005-1microRNAT-cell immunityCancer therapyBi-directional roles |
| spellingShingle | Wei He Jinzhi Xu Zhen Huang Junfeng Zhang Lei Dong MiRNAs in cancer therapy: focusing on their bi-directional roles ExRNA microRNA T-cell immunity Cancer therapy Bi-directional roles |
| title | MiRNAs in cancer therapy: focusing on their bi-directional roles |
| title_full | MiRNAs in cancer therapy: focusing on their bi-directional roles |
| title_fullStr | MiRNAs in cancer therapy: focusing on their bi-directional roles |
| title_full_unstemmed | MiRNAs in cancer therapy: focusing on their bi-directional roles |
| title_short | MiRNAs in cancer therapy: focusing on their bi-directional roles |
| title_sort | mirnas in cancer therapy focusing on their bi directional roles |
| topic | microRNA T-cell immunity Cancer therapy Bi-directional roles |
| url | http://link.springer.com/article/10.1186/s41544-019-0005-1 |
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