Microneedle technology for enhanced topical treatment of skin infections
Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiori...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24005188 |
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| author | Tingting Peng Yangyan Chen Xuanyu Luan Wanshan Hu Wentao Wu Bing Guo Chao Lu Chuanbin Wu Xin Pan |
| author_facet | Tingting Peng Yangyan Chen Xuanyu Luan Wanshan Hu Wentao Wu Bing Guo Chao Lu Chuanbin Wu Xin Pan |
| author_sort | Tingting Peng |
| collection | DOAJ |
| description | Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. Also, integrating biosensing functionality to MNs offers point-of-care wearable medical devices for analyzing specific pathogens, disease status, and drug pharmacokinetics, thus providing personalized therapy for skin infections. Herein, we do a timely update on the development of MN technology in skin infection management, with a special focus on how to devise MNs for personalized antimicrobial therapy. Notably, the advantages of state-of-the-art MNs for treating skin infections are pointed out, which include hijacking sequential drug transport barriers to enhance drug delivery efficiency and delivering various therapeutics (e.g., antibiotics, antimicrobial peptides, photosensitizers, metals, sonosensitizers, nanoenzyme, living bacteria, poly ionic liquid, and nanomoter). In addition, the nanoenzyme-based multimodal antimicrobial therapy is highlighted in addressing intractable infectious wounds. Furthermore, the MN-based biosensors used to identify pathogen types, track disease status, and quantify antibiotic concentrations are summarized. The limitations of antimicrobial MNs toward clinical translation are offered regarding large-scale production, quality control, and policy guidance. Finally, the future development of biosensing MNs with easy-to-use and intelligent properties and MN-based wearable drug delivery for home-based therapy are prospected. We hope this review will provide valuable guidance for future development in MN-mediated topical treatment of skin infections. |
| format | Article |
| id | doaj-art-0ed6e9089d6446ec9d8b89d694e24b81 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-0ed6e9089d6446ec9d8b89d694e24b812025-01-26T05:04:24ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-0145274300Microneedle technology for enhanced topical treatment of skin infectionsTingting Peng0Yangyan Chen1Xuanyu Luan2Wanshan Hu3Wentao Wu4Bing Guo5Chao Lu6Chuanbin Wu7Xin Pan8State Key Laboratory of Bioactive Molecules and Druggability Assessment/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou 511436, China; Corresponding author. College of Pharmacy, Jinan University, Guangzhou 511436, China.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaDepartment of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W12 0NN, UKState Key Laboratory of Bioactive Molecules and Druggability Assessment/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou 511436, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaSchool of Science, Harbin Institute of Technology, Shenzhen 518055, China; Corresponding authors.State Key Laboratory of Bioactive Molecules and Druggability Assessment/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou 511436, China; Corresponding author. College of Pharmacy, Jinan University, Guangzhou 511436, China.State Key Laboratory of Bioactive Molecules and Druggability Assessment/ International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou 511436, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Corresponding authors.Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. Also, integrating biosensing functionality to MNs offers point-of-care wearable medical devices for analyzing specific pathogens, disease status, and drug pharmacokinetics, thus providing personalized therapy for skin infections. Herein, we do a timely update on the development of MN technology in skin infection management, with a special focus on how to devise MNs for personalized antimicrobial therapy. Notably, the advantages of state-of-the-art MNs for treating skin infections are pointed out, which include hijacking sequential drug transport barriers to enhance drug delivery efficiency and delivering various therapeutics (e.g., antibiotics, antimicrobial peptides, photosensitizers, metals, sonosensitizers, nanoenzyme, living bacteria, poly ionic liquid, and nanomoter). In addition, the nanoenzyme-based multimodal antimicrobial therapy is highlighted in addressing intractable infectious wounds. Furthermore, the MN-based biosensors used to identify pathogen types, track disease status, and quantify antibiotic concentrations are summarized. The limitations of antimicrobial MNs toward clinical translation are offered regarding large-scale production, quality control, and policy guidance. Finally, the future development of biosensing MNs with easy-to-use and intelligent properties and MN-based wearable drug delivery for home-based therapy are prospected. We hope this review will provide valuable guidance for future development in MN-mediated topical treatment of skin infections.http://www.sciencedirect.com/science/article/pii/S2452199X24005188MicroneedleSkin infectionTopical treatmentBiosensingDrug delivery systems |
| spellingShingle | Tingting Peng Yangyan Chen Xuanyu Luan Wanshan Hu Wentao Wu Bing Guo Chao Lu Chuanbin Wu Xin Pan Microneedle technology for enhanced topical treatment of skin infections Bioactive Materials Microneedle Skin infection Topical treatment Biosensing Drug delivery systems |
| title | Microneedle technology for enhanced topical treatment of skin infections |
| title_full | Microneedle technology for enhanced topical treatment of skin infections |
| title_fullStr | Microneedle technology for enhanced topical treatment of skin infections |
| title_full_unstemmed | Microneedle technology for enhanced topical treatment of skin infections |
| title_short | Microneedle technology for enhanced topical treatment of skin infections |
| title_sort | microneedle technology for enhanced topical treatment of skin infections |
| topic | Microneedle Skin infection Topical treatment Biosensing Drug delivery systems |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24005188 |
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