Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy
Aim This study aims to present a comprehensive international analysis of the existing techniques used in liquid biopsies and their use in isolating tumor markers to detect, predict, and monitor the results of cancer treatment.Materials and Methods We conducted a narrative review using a scoping revi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Future Science OA |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2025.2527598 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850034243998056448 |
|---|---|
| author | Fan Shen Samar A. Zailaie Brian Chiu Anthony Magliocco Consolato M. Sergi |
| author_facet | Fan Shen Samar A. Zailaie Brian Chiu Anthony Magliocco Consolato M. Sergi |
| author_sort | Fan Shen |
| collection | DOAJ |
| description | Aim This study aims to present a comprehensive international analysis of the existing techniques used in liquid biopsies and their use in isolating tumor markers to detect, predict, and monitor the results of cancer treatment.Materials and Methods We conducted a narrative review using a scoping review model based on three databases, including PubMed/Medline, Scopus, and Cochrane. The search criteria included all articles on liquid biopsy of the last five years (June 30th, 2023–Oct 30, 2024) ((liquid Biopsy) AND ((“2023/06/30”[Date – Publication]: “2024/10/30”[Date – Publication]))). We also approached gray literature on this topic. We focused on review articles as an eligibility criterion for this narrative review, but we also carried out a United States registered clinical trials review targeting immunotherapy and liquid biopsy with the limitation “recruiting” and/or “not yet recruiting” (updated on March 31, 2025).Results We screened 2645 articles from PubMed/Medline, Scopus, and Cochrane and 45 articles from the gray literature. We retrieved the full text for 325 articles. Liquid biopsies involve the extraction of tumor-derived components such as circulating tumor cells, circulating tumor DNA, and tumor extracellular vesicles from the bodily fluids of cancer patients. We found 25 United States registered governmental clinical trials targeting immunotherapy and liquid biopsy, of which 20 trials are recruiting and five trials are not yet recruiting.Discussion Developments in medicine have led to a more comprehensive understanding of tumor features, including tumor load, tumor staging, heterogeneity, gene mutations, and clonal evolution. The utilization of liquid biopsies from cancer patients has provided novel opportunities for detection and ongoing monitoring, precision medicine-based therapy, and identification of markers for therapeutic resistance. |
| format | Article |
| id | doaj-art-0ed1c0ed85714d5e935cb365a3845f4e |
| institution | DOAJ |
| issn | 2056-5623 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-0ed1c0ed85714d5e935cb365a3845f4e2025-08-20T02:57:53ZengTaylor & Francis GroupFuture Science OA2056-56232025-12-0111110.1080/20565623.2025.2527598Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapyFan Shen0Samar A. Zailaie1Brian Chiu2Anthony Magliocco3Consolato M. Sergi4Department of Laboratory Medicine, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, CanadaResearch Center, King Faisal Specialist Hospital & Research Center-Jeddah (KFSHRC-J), Jeddah, Kingdom of Saudi ArabiaDepartment of Laboratory Medicine, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, CanadaProtean BioDiagnostics Inc, Orlando, FL, USADepartment of Laboratory Medicine, Stollery Children’s Hospital, University of Alberta, Edmonton, AB, CanadaAim This study aims to present a comprehensive international analysis of the existing techniques used in liquid biopsies and their use in isolating tumor markers to detect, predict, and monitor the results of cancer treatment.Materials and Methods We conducted a narrative review using a scoping review model based on three databases, including PubMed/Medline, Scopus, and Cochrane. The search criteria included all articles on liquid biopsy of the last five years (June 30th, 2023–Oct 30, 2024) ((liquid Biopsy) AND ((“2023/06/30”[Date – Publication]: “2024/10/30”[Date – Publication]))). We also approached gray literature on this topic. We focused on review articles as an eligibility criterion for this narrative review, but we also carried out a United States registered clinical trials review targeting immunotherapy and liquid biopsy with the limitation “recruiting” and/or “not yet recruiting” (updated on March 31, 2025).Results We screened 2645 articles from PubMed/Medline, Scopus, and Cochrane and 45 articles from the gray literature. We retrieved the full text for 325 articles. Liquid biopsies involve the extraction of tumor-derived components such as circulating tumor cells, circulating tumor DNA, and tumor extracellular vesicles from the bodily fluids of cancer patients. We found 25 United States registered governmental clinical trials targeting immunotherapy and liquid biopsy, of which 20 trials are recruiting and five trials are not yet recruiting.Discussion Developments in medicine have led to a more comprehensive understanding of tumor features, including tumor load, tumor staging, heterogeneity, gene mutations, and clonal evolution. The utilization of liquid biopsies from cancer patients has provided novel opportunities for detection and ongoing monitoring, precision medicine-based therapy, and identification of markers for therapeutic resistance.https://www.tandfonline.com/doi/10.1080/20565623.2025.2527598Liquid biopsycancercirculating tumor cellscirculating tumor DNAtumor extracellular vesiclesproteomics |
| spellingShingle | Fan Shen Samar A. Zailaie Brian Chiu Anthony Magliocco Consolato M. Sergi Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy Future Science OA Liquid biopsy cancer circulating tumor cells circulating tumor DNA tumor extracellular vesicles proteomics |
| title | Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy |
| title_full | Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy |
| title_fullStr | Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy |
| title_full_unstemmed | Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy |
| title_short | Liquid biopsy – a narrative review with an update on current US governmental clinical trials targeting immunotherapy |
| title_sort | liquid biopsy a narrative review with an update on current us governmental clinical trials targeting immunotherapy |
| topic | Liquid biopsy cancer circulating tumor cells circulating tumor DNA tumor extracellular vesicles proteomics |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2025.2527598 |
| work_keys_str_mv | AT fanshen liquidbiopsyanarrativereviewwithanupdateoncurrentusgovernmentalclinicaltrialstargetingimmunotherapy AT samarazailaie liquidbiopsyanarrativereviewwithanupdateoncurrentusgovernmentalclinicaltrialstargetingimmunotherapy AT brianchiu liquidbiopsyanarrativereviewwithanupdateoncurrentusgovernmentalclinicaltrialstargetingimmunotherapy AT anthonymagliocco liquidbiopsyanarrativereviewwithanupdateoncurrentusgovernmentalclinicaltrialstargetingimmunotherapy AT consolatomsergi liquidbiopsyanarrativereviewwithanupdateoncurrentusgovernmentalclinicaltrialstargetingimmunotherapy |