Opportunities for the treatment of atherosclerosis: Selectins
Despite the widespread availability of selectins for tumor therapy, their contribution to atherosclerosis has long been under-emphasized due to their “cofactor’s” status and technological limitations. However, advances in immunohistology, glycomics, and related technologies require us to reassess th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002324 |
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| author | Nong Li Chao Pi Siying Zhu Xiumei Li Liu Wang Peng Shi Ying Zuo Wenwu Zheng Jun Jiang Yan Yang Qiong Zhang Lei Tao Shifeng Chu Yumeng Wei Ling Zhao |
| author_facet | Nong Li Chao Pi Siying Zhu Xiumei Li Liu Wang Peng Shi Ying Zuo Wenwu Zheng Jun Jiang Yan Yang Qiong Zhang Lei Tao Shifeng Chu Yumeng Wei Ling Zhao |
| author_sort | Nong Li |
| collection | DOAJ |
| description | Despite the widespread availability of selectins for tumor therapy, their contribution to atherosclerosis has long been under-emphasized due to their “cofactor’s” status and technological limitations. However, advances in immunohistology, glycomics, and related technologies require us to reassess their relationship. Thus, this review identifies pivotal translational opportunities from the intricate mechanisms and explores the clinical promise of selectins in the diagnosis and treatment of atherosclerosis based on the latest clinical research. This review provides insights into selectin-specific tracers and inhibitors, providing lessons for more precise diagnosis and treatment of patients with atherosclerosis. |
| format | Article |
| id | doaj-art-0ed059a696ab4110a9ef57f3e08ecdc5 |
| institution | DOAJ |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-0ed059a696ab4110a9ef57f3e08ecdc52025-08-20T03:07:51ZengElsevierPharmacological Research1096-11862025-07-0121710780710.1016/j.phrs.2025.107807Opportunities for the treatment of atherosclerosis: SelectinsNong Li0Chao Pi1Siying Zhu2Xiumei Li3Liu Wang4Peng Shi5Ying Zuo6Wenwu Zheng7Jun Jiang8Yan Yang9Qiong Zhang10Lei Tao11Shifeng Chu12Yumeng Wei13Ling Zhao14Key Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaCentral Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaCentral Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaCentral Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaDepartment of Comprehensive Medicine, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, PR ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, PR ChinaDepartment of Cardiology, The Affiliated Hospital of Southwest Medical University, PR ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaKey Laboratory of Medical Electrophysiology, Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou 646000, PR China; Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR ChinaState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, PR China; Correspondence to: State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Correspondence to: Central Nervous System Product Research and Development Key 25 Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, 26 Luzhou, Sichuan, 646000, China.Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Central Nervous System Product Research and Development Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, PR China; Corresponding author at: Luzhou Key Laboratory of Traditional Chinese Medicine for Chronic Diseases Jointly Built by Sichuan and Chongqing, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646000, PR China.Despite the widespread availability of selectins for tumor therapy, their contribution to atherosclerosis has long been under-emphasized due to their “cofactor’s” status and technological limitations. However, advances in immunohistology, glycomics, and related technologies require us to reassess their relationship. Thus, this review identifies pivotal translational opportunities from the intricate mechanisms and explores the clinical promise of selectins in the diagnosis and treatment of atherosclerosis based on the latest clinical research. This review provides insights into selectin-specific tracers and inhibitors, providing lessons for more precise diagnosis and treatment of patients with atherosclerosis.http://www.sciencedirect.com/science/article/pii/S1043661825002324SelectinsAtherosclerosisTranslational medicine |
| spellingShingle | Nong Li Chao Pi Siying Zhu Xiumei Li Liu Wang Peng Shi Ying Zuo Wenwu Zheng Jun Jiang Yan Yang Qiong Zhang Lei Tao Shifeng Chu Yumeng Wei Ling Zhao Opportunities for the treatment of atherosclerosis: Selectins Pharmacological Research Selectins Atherosclerosis Translational medicine |
| title | Opportunities for the treatment of atherosclerosis: Selectins |
| title_full | Opportunities for the treatment of atherosclerosis: Selectins |
| title_fullStr | Opportunities for the treatment of atherosclerosis: Selectins |
| title_full_unstemmed | Opportunities for the treatment of atherosclerosis: Selectins |
| title_short | Opportunities for the treatment of atherosclerosis: Selectins |
| title_sort | opportunities for the treatment of atherosclerosis selectins |
| topic | Selectins Atherosclerosis Translational medicine |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002324 |
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