Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice
Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. The aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential....
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/281097 |
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| author | Gabriel Inácio de Morais Honorato de Souza Aline Boveto Santamarina Aline Alves de Santana Fábio Santos Lira Rachel de Laquila Mayara Franzoi Moreno Eliane Beraldi Ribeiro Claudia Maria da Penha Oller do Nascimento Bruno Rodrigues Elisa Esposito Lila Missae Oyama |
| author_facet | Gabriel Inácio de Morais Honorato de Souza Aline Boveto Santamarina Aline Alves de Santana Fábio Santos Lira Rachel de Laquila Mayara Franzoi Moreno Eliane Beraldi Ribeiro Claudia Maria da Penha Oller do Nascimento Bruno Rodrigues Elisa Esposito Lila Missae Oyama |
| author_sort | Gabriel Inácio de Morais Honorato de Souza |
| collection | DOAJ |
| description | Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. The aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential. Methods. CWP (100 mg·kg·day) was administered in mice with diet-induced obesity for 8 weeks. The animals were divided into four groups: control normocaloric diet gavage with water (C) or coacervate (C-CWP), and high fat diet gavage with water (HF) or coacervate (HF-CWP). Results. HF-CWP reduced weight gain and serum lipid fractions and displayed reduced adiposity and insulin. Adiponectin was significantly higher in HF-CWP group when compared to the HF. The level of LPS in HF-W group was significantly higher when compared to HF-CWP. The IL-10 showed an inverse correlation between the levels of insulin and glucose in the mesenteric adipose tissue in the HF-CWP group. CWP promoted an increase in both phosphorylation AMPK and the amount of ATGL in the mesenteric adipose tissue in HF-CWP group. Conclusion. CWP was able to modulate effects, possibly due to its high biological value of proteins. We observed a protective effect against obesity and improved the inflammatory milieu of white adipose tissue. |
| format | Article |
| id | doaj-art-0ed01657e398496b807f2ba93eff6b1c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0ed01657e398496b807f2ba93eff6b1c2025-08-20T03:54:30ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/281097281097Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese MiceGabriel Inácio de Morais Honorato de Souza0Aline Boveto Santamarina1Aline Alves de Santana2Fábio Santos Lira3Rachel de Laquila4Mayara Franzoi Moreno5Eliane Beraldi Ribeiro6Claudia Maria da Penha Oller do Nascimento7Bruno Rodrigues8Elisa Esposito9Lila Missae Oyama10Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Educação Física da Universidade Estadual Paulista, Faculdade de Ciências e Tecnologia, 19060-900 Presidente Prudente, SP, BrazilDepartamento de Nutrição das Faculdades Integradas Coração de Jesus-FAINC, 09020-240 Santo André, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilDepartamento de Ciências Biológicas, Laboratório de Movimento Humano da Universidade São Judas Tadeu, 03166-000 São Paulo, SP, BrazilInstituto de Ciências e Tecnologia da Universidade Federal de São Paulo, 04023-060 São José dos Campos, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, BrazilFunctional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. The aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential. Methods. CWP (100 mg·kg·day) was administered in mice with diet-induced obesity for 8 weeks. The animals were divided into four groups: control normocaloric diet gavage with water (C) or coacervate (C-CWP), and high fat diet gavage with water (HF) or coacervate (HF-CWP). Results. HF-CWP reduced weight gain and serum lipid fractions and displayed reduced adiposity and insulin. Adiponectin was significantly higher in HF-CWP group when compared to the HF. The level of LPS in HF-W group was significantly higher when compared to HF-CWP. The IL-10 showed an inverse correlation between the levels of insulin and glucose in the mesenteric adipose tissue in the HF-CWP group. CWP promoted an increase in both phosphorylation AMPK and the amount of ATGL in the mesenteric adipose tissue in HF-CWP group. Conclusion. CWP was able to modulate effects, possibly due to its high biological value of proteins. We observed a protective effect against obesity and improved the inflammatory milieu of white adipose tissue.http://dx.doi.org/10.1155/2014/281097 |
| spellingShingle | Gabriel Inácio de Morais Honorato de Souza Aline Boveto Santamarina Aline Alves de Santana Fábio Santos Lira Rachel de Laquila Mayara Franzoi Moreno Eliane Beraldi Ribeiro Claudia Maria da Penha Oller do Nascimento Bruno Rodrigues Elisa Esposito Lila Missae Oyama Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice Mediators of Inflammation |
| title | Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice |
| title_full | Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice |
| title_fullStr | Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice |
| title_full_unstemmed | Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice |
| title_short | Preventive Effects of Chitosan Coacervate Whey Protein on Body Composition and Immunometabolic Aspect in Obese Mice |
| title_sort | preventive effects of chitosan coacervate whey protein on body composition and immunometabolic aspect in obese mice |
| url | http://dx.doi.org/10.1155/2014/281097 |
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