Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome
The goal was to identify the changes in blood levels of hormones, cytokines, and the number of leukocytes associated with the success of laser treatment of hypertrophic scars. Material and Methods — The lipid, hormonal, cytokine and leukocyte composition of blood was studied in 15 women with normotr...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2022-09-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/498 |
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| _version_ | 1849735588956078080 |
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| author | Lyudmila S. Vasilyeva Maksim V. Kobets Olga A. Makarova |
| author_facet | Lyudmila S. Vasilyeva Maksim V. Kobets Olga A. Makarova |
| author_sort | Lyudmila S. Vasilyeva |
| collection | DOAJ |
| description | The goal was to identify the changes in blood levels of hormones, cytokines, and the number of leukocytes associated with the success of laser treatment of hypertrophic scars.
Material and Methods — The lipid, hormonal, cytokine and leukocyte composition of blood was studied in 15 women with normotrophic scars (Group 1) and 30 women with hypertrophic scars (Group 2). Blood was taken before treatment on days 5-7 of the menstrual cycle, followed by laser treatment. The clinical parameters of scars were assessed before treatment and 3 months after it, and two subgroups were identified: with a successful treatment outcome (2a) and with an unsuccessful outcome (2b). A retrospective analysis of blood composition was performed in each subgroup. The data were processed using the methods of nonparametric statistics. The differences were considered statistically significant at p<0.05.
Results — At a successful treatment outcome, the clinical parameters of scars were associated with low estradiol level, high progesterone content and high number of segmented neutrophils. These changes create conditions for scar hypertrophy, but retain the body’s capability of responding to the treatment by inflammatory process with normotrophic scarring. At an unsuccessful treatment outcome, the scar hypertrophy was restored under conditions of low blood content of luteinizing hormone, and high levels of growth hormone and transforming growth factor β.
Conclusion — Features of changes in the blood levels of hormones, cytokines, and leukocyte content are associated with the success of laser treatment of hypertrophic scars. |
| format | Article |
| id | doaj-art-0ecffe060b584978b15efa7541273fbb |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-0ecffe060b584978b15efa7541273fbb2025-08-20T03:07:32ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152022-09-01113e030310.15275/rusomj.2022.0303Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcomeLyudmila S. VasilyevaMaksim V. KobetsOlga A. MakarovaThe goal was to identify the changes in blood levels of hormones, cytokines, and the number of leukocytes associated with the success of laser treatment of hypertrophic scars. Material and Methods — The lipid, hormonal, cytokine and leukocyte composition of blood was studied in 15 women with normotrophic scars (Group 1) and 30 women with hypertrophic scars (Group 2). Blood was taken before treatment on days 5-7 of the menstrual cycle, followed by laser treatment. The clinical parameters of scars were assessed before treatment and 3 months after it, and two subgroups were identified: with a successful treatment outcome (2a) and with an unsuccessful outcome (2b). A retrospective analysis of blood composition was performed in each subgroup. The data were processed using the methods of nonparametric statistics. The differences were considered statistically significant at p<0.05. Results — At a successful treatment outcome, the clinical parameters of scars were associated with low estradiol level, high progesterone content and high number of segmented neutrophils. These changes create conditions for scar hypertrophy, but retain the body’s capability of responding to the treatment by inflammatory process with normotrophic scarring. At an unsuccessful treatment outcome, the scar hypertrophy was restored under conditions of low blood content of luteinizing hormone, and high levels of growth hormone and transforming growth factor β. Conclusion — Features of changes in the blood levels of hormones, cytokines, and leukocyte content are associated with the success of laser treatment of hypertrophic scars.https://romj.org/node/498cytokineshypertrophic scarssystemic factorshormonesnumber of neutrophils |
| spellingShingle | Lyudmila S. Vasilyeva Maksim V. Kobets Olga A. Makarova Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome Russian Open Medical Journal cytokines hypertrophic scars systemic factors hormones number of neutrophils |
| title | Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| title_full | Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| title_fullStr | Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| title_full_unstemmed | Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| title_short | Blood levels of hormones, cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| title_sort | blood levels of hormones cytokines and leukocyte content versus hypertrophic scar laser treatment outcome |
| topic | cytokines hypertrophic scars systemic factors hormones number of neutrophils |
| url | https://romj.org/node/498 |
| work_keys_str_mv | AT lyudmilasvasilyeva bloodlevelsofhormonescytokinesandleukocytecontentversushypertrophicscarlasertreatmentoutcome AT maksimvkobets bloodlevelsofhormonescytokinesandleukocytecontentversushypertrophicscarlasertreatmentoutcome AT olgaamakarova bloodlevelsofhormonescytokinesandleukocytecontentversushypertrophicscarlasertreatmentoutcome |