Detection of FSH receptors in mouse and human penile tissue
Background: This study aims to investigate the expression of follicle-stimulating hormone (FSH) receptors in both mouse and human penis to explore its potential impact on penis function. Methods: We utilized immunohistochemistry to detect FSH receptors in penile and testicular tissues from 12 BA...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2025-04-01
|
| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20250428-534/pdf/JOMH2024121902.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728078617509888 |
|---|---|
| author | Helen Zirnask Pasi Pöllänen Siim Suutre Taavi Torga Samuel Rüsse Liis Salumäe Andres Kotsar Kersti Kokk |
| author_facet | Helen Zirnask Pasi Pöllänen Siim Suutre Taavi Torga Samuel Rüsse Liis Salumäe Andres Kotsar Kersti Kokk |
| author_sort | Helen Zirnask |
| collection | DOAJ |
| description | Background: This study aims to investigate the expression of
follicle-stimulating hormone (FSH) receptors in both mouse and human penis to
explore its potential impact on penis function. Methods: We utilized
immunohistochemistry to detect FSH receptors in penile and testicular tissues
from 12 BALB/c mice, as well as penile tissues from three patients undergoing
penectomy for squamous cell carcinoma. Results: Positive immunoreaction
for FSH receptors was detected in tissue samples of all patients including
sebaceous gland, epithelial layers, subepithelial fibroblasts, corpus cavernosum
cells, walls of small blood vessels and plasma cells. However, species
specificity was observed in the results, as positive immunoreaction was absent in
the most of mouse penis tissue samples. Fibrocytes and mast cells in the mouse
penis exhibited negligible positive immunoreaction. Conclusions: This
study marks the first reported detection of FSH receptors in human penile tissue,
highlighting a potential extragonadal role for FSH in penile function. While
human tissues exhibited widespread receptor expression, mouse tissues showed
minimal immunoreactivity, suggesting species-specific expression patterns. These
preliminary findings indicate a possible regulatory role for FSH in human penile
physiology, meriting further exploration in subsequent studies. |
| format | Article |
| id | doaj-art-0ecf1d82765e4d379fd001c934ffd9e3 |
| institution | DOAJ |
| issn | 1875-6867 1875-6859 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj-art-0ecf1d82765e4d379fd001c934ffd9e32025-08-20T03:09:39ZengMRE PressJournal of Men's Health1875-68671875-68592025-04-0121410210510.22514/jomh.2025.057S1875-6867(25)00374-4Detection of FSH receptors in mouse and human penile tissueHelen Zirnask0Pasi Pöllänen1Siim Suutre2Taavi Torga3Samuel Rüsse4Liis Salumäe5Andres Kotsar6Kersti Kokk7Department of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaDepartment of Anatomy, Institute of Biomedicine, University of Turku, 20014 Turku, FinlandDepartment of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaDepartment of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaDepartment of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaPathology Service, Tartu University Hospital, 50406 Tartu, EstoniaDepartment of Urology, Tartu University Hospital, 50406 Tartu, EstoniaDepartment of Anatomy, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, EstoniaBackground: This study aims to investigate the expression of follicle-stimulating hormone (FSH) receptors in both mouse and human penis to explore its potential impact on penis function. Methods: We utilized immunohistochemistry to detect FSH receptors in penile and testicular tissues from 12 BALB/c mice, as well as penile tissues from three patients undergoing penectomy for squamous cell carcinoma. Results: Positive immunoreaction for FSH receptors was detected in tissue samples of all patients including sebaceous gland, epithelial layers, subepithelial fibroblasts, corpus cavernosum cells, walls of small blood vessels and plasma cells. However, species specificity was observed in the results, as positive immunoreaction was absent in the most of mouse penis tissue samples. Fibrocytes and mast cells in the mouse penis exhibited negligible positive immunoreaction. Conclusions: This study marks the first reported detection of FSH receptors in human penile tissue, highlighting a potential extragonadal role for FSH in penile function. While human tissues exhibited widespread receptor expression, mouse tissues showed minimal immunoreactivity, suggesting species-specific expression patterns. These preliminary findings indicate a possible regulatory role for FSH in human penile physiology, meriting further exploration in subsequent studies.https://oss.jomh.org/files/article/20250428-534/pdf/JOMH2024121902.pdffollicle-stimulating hormonefollicle-stimulating hormone receptorcorpus cavernosum penis |
| spellingShingle | Helen Zirnask Pasi Pöllänen Siim Suutre Taavi Torga Samuel Rüsse Liis Salumäe Andres Kotsar Kersti Kokk Detection of FSH receptors in mouse and human penile tissue Journal of Men's Health follicle-stimulating hormone follicle-stimulating hormone receptor corpus cavernosum penis |
| title | Detection of FSH receptors in mouse and human penile tissue |
| title_full | Detection of FSH receptors in mouse and human penile tissue |
| title_fullStr | Detection of FSH receptors in mouse and human penile tissue |
| title_full_unstemmed | Detection of FSH receptors in mouse and human penile tissue |
| title_short | Detection of FSH receptors in mouse and human penile tissue |
| title_sort | detection of fsh receptors in mouse and human penile tissue |
| topic | follicle-stimulating hormone follicle-stimulating hormone receptor corpus cavernosum penis |
| url | https://oss.jomh.org/files/article/20250428-534/pdf/JOMH2024121902.pdf |
| work_keys_str_mv | AT helenzirnask detectionoffshreceptorsinmouseandhumanpeniletissue AT pasipollanen detectionoffshreceptorsinmouseandhumanpeniletissue AT siimsuutre detectionoffshreceptorsinmouseandhumanpeniletissue AT taavitorga detectionoffshreceptorsinmouseandhumanpeniletissue AT samuelrusse detectionoffshreceptorsinmouseandhumanpeniletissue AT liissalumae detectionoffshreceptorsinmouseandhumanpeniletissue AT andreskotsar detectionoffshreceptorsinmouseandhumanpeniletissue AT kerstikokk detectionoffshreceptorsinmouseandhumanpeniletissue |