Detection of FSH receptors in mouse and human penile tissue
Background: This study aims to investigate the expression of follicle-stimulating hormone (FSH) receptors in both mouse and human penis to explore its potential impact on penis function. Methods: We utilized immunohistochemistry to detect FSH receptors in penile and testicular tissues from 12 BA...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2025-04-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20250428-534/pdf/JOMH2024121902.pdf |
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| Summary: | Background: This study aims to investigate the expression of
follicle-stimulating hormone (FSH) receptors in both mouse and human penis to
explore its potential impact on penis function. Methods: We utilized
immunohistochemistry to detect FSH receptors in penile and testicular tissues
from 12 BALB/c mice, as well as penile tissues from three patients undergoing
penectomy for squamous cell carcinoma. Results: Positive immunoreaction
for FSH receptors was detected in tissue samples of all patients including
sebaceous gland, epithelial layers, subepithelial fibroblasts, corpus cavernosum
cells, walls of small blood vessels and plasma cells. However, species
specificity was observed in the results, as positive immunoreaction was absent in
the most of mouse penis tissue samples. Fibrocytes and mast cells in the mouse
penis exhibited negligible positive immunoreaction. Conclusions: This
study marks the first reported detection of FSH receptors in human penile tissue,
highlighting a potential extragonadal role for FSH in penile function. While
human tissues exhibited widespread receptor expression, mouse tissues showed
minimal immunoreactivity, suggesting species-specific expression patterns. These
preliminary findings indicate a possible regulatory role for FSH in human penile
physiology, meriting further exploration in subsequent studies. |
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| ISSN: | 1875-6867 1875-6859 |