Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging
Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging. Mass spectrometry-based...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/908035 |
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| _version_ | 1849308661073051648 |
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| author | Lisa Staunton Kathleen O'Connell Kay Ohlendieck |
| author_facet | Lisa Staunton Kathleen O'Connell Kay Ohlendieck |
| author_sort | Lisa Staunton |
| collection | DOAJ |
| description | Mitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging. Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach to catalogue the mitochondrial protein complement and determine global changes during health and disease. This paper gives a brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of mitochondrial elements in aged skeletal muscles. Changes in the abundance, biochemical activity, subcellular localization, and/or posttranslational modifications in key mitochondrial enzymes might be useful as novel biomarkers of aging. In the long term, this may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new drug regimes, and enhance our molecular understanding of age-related muscle degeneration. |
| format | Article |
| id | doaj-art-0ecd6bbad0bc41dda9389e10e347af92 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-0ecd6bbad0bc41dda9389e10e347af922025-08-20T03:54:24ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/908035908035Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle AgingLisa Staunton0Kathleen O'Connell1Kay Ohlendieck2Department of Biology, National University of Ireland, Maynooth, County Kildare, IrelandNational Institute for Cellular Biotechnology, Dublin City University, Dublin 9, IrelandDepartment of Biology, National University of Ireland, Maynooth, County Kildare, IrelandMitochondria are of central importance for energy generation in skeletal muscles. Expression changes or functional alterations in mitochondrial enzymes play a key role during myogenesis, fibre maturation, and various neuromuscular pathologies, as well as natural fibre aging. Mass spectrometry-based proteomics suggests itself as a convenient large-scale and high-throughput approach to catalogue the mitochondrial protein complement and determine global changes during health and disease. This paper gives a brief overview of the relatively new field of mitochondrial proteomics and discusses the findings from recent proteomic surveys of mitochondrial elements in aged skeletal muscles. Changes in the abundance, biochemical activity, subcellular localization, and/or posttranslational modifications in key mitochondrial enzymes might be useful as novel biomarkers of aging. In the long term, this may advance diagnostic procedures, improve the monitoring of disease progression, help in the testing of side effects due to new drug regimes, and enhance our molecular understanding of age-related muscle degeneration.http://dx.doi.org/10.4061/2011/908035 |
| spellingShingle | Lisa Staunton Kathleen O'Connell Kay Ohlendieck Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging Journal of Aging Research |
| title | Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging |
| title_full | Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging |
| title_fullStr | Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging |
| title_full_unstemmed | Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging |
| title_short | Proteomic Profiling of Mitochondrial Enzymes during Skeletal Muscle Aging |
| title_sort | proteomic profiling of mitochondrial enzymes during skeletal muscle aging |
| url | http://dx.doi.org/10.4061/2011/908035 |
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