Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma
Flow Cytometry (FC) has been incorporated into cancer research in relation to its prognostic value together with histological parameters and TNM stages. We have studied by means of FC the cell cycle of 132 samples from male patients with Squamous Cell Lung Carcinoma (SQCLC). All of the patients rece...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1998-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/1998/974145 |
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| _version_ | 1832563614566842368 |
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| author | José Antonio Alvarez-Riesgo Andrés Sampedro Radhamés Hernández María Victoria Folgueras Ana Salas-Bustamante Antonio Cueto |
| author_facet | José Antonio Alvarez-Riesgo Andrés Sampedro Radhamés Hernández María Victoria Folgueras Ana Salas-Bustamante Antonio Cueto |
| author_sort | José Antonio Alvarez-Riesgo |
| collection | DOAJ |
| description | Flow Cytometry (FC) has been incorporated into cancer research in relation to its prognostic value together with histological parameters and TNM stages. We have studied by means of FC the cell cycle of 132 samples from male patients with Squamous Cell Lung Carcinoma (SQCLC). All of the patients received curative surgery and the clinical follow-up was 60 months. The clinical and cytometric parameters were evaluated in order to predict the patients’ outcome. The presence of tumoural recurrence and the tumoural stage showed statistical significance associated with survival. The multivariant analysis reveals radiotherapy (p = 0.004) as protective variable and the high S-phase fraction (SPF) (p = 0.001) and stage IIIA (p = 0.012) as risk factors. The SPF appears as an independent prognostic factor for overall survival time. We can build a prognostic index representative of different prognostic groups, which allows us to improve the individual monitoring of these patients. |
| format | Article |
| id | doaj-art-0eccce673ab0469fab2468025ffdf333 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-0eccce673ab0469fab2468025ffdf3332025-02-03T01:12:58ZengWileyAnalytical Cellular Pathology0921-89121878-36511998-01-0116423324210.1155/1998/974145Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung CarcinomaJosé Antonio Alvarez-Riesgo0Andrés Sampedro1Radhamés Hernández2María Victoria Folgueras3Ana Salas-Bustamante4Antonio Cueto5Departamento de Medicina, Universidad de Oviedo, Facultad de Medicina, C/ Julián Clavería s/n, 33006 Oviedo, SpainServicio de Citometría, Hospital Central de Asturias, Bloque Polivante A, 1a Planta, C/ Celestino Villamil s/n, 33006 Oviedo, SpainDepartamento de Medicina, Universidad de Oviedo, Facultad de Medicina, C/ Julián Clavería s/n, 33006 Oviedo, SpainServicio de Anatomía Patolögica II, Hospital Central de Asturias, C/ Celestino Villamil s/n, 33006 Oviedo, SpainServicio de Citometría, Hospital Central de Asturias, Bloque Polivante A, 1a Planta, C/ Celestino Villamil s/n, 33006 Oviedo, SpainDepartamento de Medicina, Universidad de Oviedo, Facultad de Medicina, C/ Julián Clavería s/n, 33006 Oviedo, SpainFlow Cytometry (FC) has been incorporated into cancer research in relation to its prognostic value together with histological parameters and TNM stages. We have studied by means of FC the cell cycle of 132 samples from male patients with Squamous Cell Lung Carcinoma (SQCLC). All of the patients received curative surgery and the clinical follow-up was 60 months. The clinical and cytometric parameters were evaluated in order to predict the patients’ outcome. The presence of tumoural recurrence and the tumoural stage showed statistical significance associated with survival. The multivariant analysis reveals radiotherapy (p = 0.004) as protective variable and the high S-phase fraction (SPF) (p = 0.001) and stage IIIA (p = 0.012) as risk factors. The SPF appears as an independent prognostic factor for overall survival time. We can build a prognostic index representative of different prognostic groups, which allows us to improve the individual monitoring of these patients.http://dx.doi.org/10.1155/1998/974145 |
| spellingShingle | José Antonio Alvarez-Riesgo Andrés Sampedro Radhamés Hernández María Victoria Folgueras Ana Salas-Bustamante Antonio Cueto Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma Analytical Cellular Pathology |
| title | Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma |
| title_full | Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma |
| title_fullStr | Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma |
| title_full_unstemmed | Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma |
| title_short | Cell Proliferation Activity and Prognostic Index in Squamous Cell Lung Carcinoma |
| title_sort | cell proliferation activity and prognostic index in squamous cell lung carcinoma |
| url | http://dx.doi.org/10.1155/1998/974145 |
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