Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article
Acute myeloid leukemia (AML) is an immensely heterogeneous disease characterized by the clonal growth of promyelocytes or myeloblasts in bone marrow as well as in peripheral blood or tissue. Enhancement in the knowledge of the molecular biology of cancer and recognition of intermittent mutations in...
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KeAi Communications Co., Ltd.
2023-06-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770768 |
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| author | Himanshu Singh Magesh Kumar Himanshu Kanungo |
| author_facet | Himanshu Singh Magesh Kumar Himanshu Kanungo |
| author_sort | Himanshu Singh |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) is an immensely heterogeneous disease characterized by the clonal growth of promyelocytes or myeloblasts in bone marrow as well as in peripheral blood or tissue. Enhancement in the knowledge of the molecular biology of cancer and recognition of intermittent mutations in AML contribute to favorable circumstances to establish targeted therapies and enhance the clinical outcome. There is high interest in the development of therapies that target definitive abnormalities in AML while eradicating leukemia-initiating cells. In recent years, there has been a better knowledge of the molecular abnormalities that lead to the progression of AML, and the application of new methods in molecular biology techniques has increased that facilitating the advancement of investigational drugs. In this review, literature or information on various gene mutations for AML is discussed. English language articles were scrutinized in plentiful directories or databases like PubMed, Science Direct, Web of Sciences, Google Scholar, and Scopus. The important keywords used for searching databases is “Acute myeloid leukemia”, “Gene mutation in Acute myeloid leukemia”, “Genetic alteration in Acute myeloid leukemia,” and “Genetic abnormalities in Acute myeloid leukemia.” |
| format | Article |
| id | doaj-art-0eca5b7c1d0f43e2b55d3fcd58aaeb16 |
| institution | OA Journals |
| issn | 2699-9404 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj-art-0eca5b7c1d0f43e2b55d3fcd58aaeb162025-08-20T02:23:53ZengKeAi Communications Co., Ltd.Global Medical Genetics2699-94042023-06-01100212312810.1055/s-0043-1770768Role of Gene Mutations in Acute Myeloid Leukemia: A Review ArticleHimanshu Singh0Magesh Kumar1Himanshu Kanungo2Department of Oral and Maxillofacial Pathology and Oral Microbiology, Index Institute of Dental Sciences, Indore, Madhya Pradesh, IndiaDepartment of Periodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, IndiaDepartment of Orthodontics and Dentofacial Orthopaedics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, IndiaAcute myeloid leukemia (AML) is an immensely heterogeneous disease characterized by the clonal growth of promyelocytes or myeloblasts in bone marrow as well as in peripheral blood or tissue. Enhancement in the knowledge of the molecular biology of cancer and recognition of intermittent mutations in AML contribute to favorable circumstances to establish targeted therapies and enhance the clinical outcome. There is high interest in the development of therapies that target definitive abnormalities in AML while eradicating leukemia-initiating cells. In recent years, there has been a better knowledge of the molecular abnormalities that lead to the progression of AML, and the application of new methods in molecular biology techniques has increased that facilitating the advancement of investigational drugs. In this review, literature or information on various gene mutations for AML is discussed. English language articles were scrutinized in plentiful directories or databases like PubMed, Science Direct, Web of Sciences, Google Scholar, and Scopus. The important keywords used for searching databases is “Acute myeloid leukemia”, “Gene mutation in Acute myeloid leukemia”, “Genetic alteration in Acute myeloid leukemia,” and “Genetic abnormalities in Acute myeloid leukemia.”http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770768acute myeloid leukemiagene mutationgenetic alteration |
| spellingShingle | Himanshu Singh Magesh Kumar Himanshu Kanungo Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article Global Medical Genetics acute myeloid leukemia gene mutation genetic alteration |
| title | Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article |
| title_full | Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article |
| title_fullStr | Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article |
| title_full_unstemmed | Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article |
| title_short | Role of Gene Mutations in Acute Myeloid Leukemia: A Review Article |
| title_sort | role of gene mutations in acute myeloid leukemia a review article |
| topic | acute myeloid leukemia gene mutation genetic alteration |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1770768 |
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