Anterior Segment Imaging in Ocular Surface Squamous Neoplasia
Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVC...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/5435092 |
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| author | Sally S. Ong Gargi K. Vora Preeya K. Gupta |
| author_facet | Sally S. Ong Gargi K. Vora Preeya K. Gupta |
| author_sort | Sally S. Ong |
| collection | DOAJ |
| description | Recent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings. Although there are limitations to each of these imaging modalities, they can be useful adjunctive tools in the diagnosis of OSSN and could greatly assist the clinician in the management of OSSN patients. Nevertheless, anterior segment imaging has not replaced histopathology’s role as the gold standard in confirming diagnosis. |
| format | Article |
| id | doaj-art-0ec9d69da5e942bfacea53af8cda1129 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0ec9d69da5e942bfacea53af8cda11292025-02-03T05:46:55ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/54350925435092Anterior Segment Imaging in Ocular Surface Squamous NeoplasiaSally S. Ong0Gargi K. Vora1Preeya K. Gupta2Duke University Department of Ophthalmology, Durham, NC, USADuke University Department of Ophthalmology, Durham, NC, USADuke University Department of Ophthalmology, Durham, NC, USARecent advances in anterior segment imaging have transformed the way ocular surface squamous neoplasia (OSSN) is diagnosed and monitored. Ultrasound biomicroscopy (UBM) has been reported to be useful primarily in the assessment of intraocular invasion and metastasis. In vivo confocal microscopy (IVCM) shows enlarged and irregular nuclei with hyperreflective cells in OSSN lesions and this has been found to correlate with histopathology findings. Anterior segment optical coherence tomography (AS-OCT) demonstrates thickened hyperreflective epithelium with an abrupt transition between abnormal and normal epithelium in OSSN lesions and this has also been shown to mimic histopathology findings. Although there are limitations to each of these imaging modalities, they can be useful adjunctive tools in the diagnosis of OSSN and could greatly assist the clinician in the management of OSSN patients. Nevertheless, anterior segment imaging has not replaced histopathology’s role as the gold standard in confirming diagnosis.http://dx.doi.org/10.1155/2016/5435092 |
| spellingShingle | Sally S. Ong Gargi K. Vora Preeya K. Gupta Anterior Segment Imaging in Ocular Surface Squamous Neoplasia Journal of Ophthalmology |
| title | Anterior Segment Imaging in Ocular Surface Squamous Neoplasia |
| title_full | Anterior Segment Imaging in Ocular Surface Squamous Neoplasia |
| title_fullStr | Anterior Segment Imaging in Ocular Surface Squamous Neoplasia |
| title_full_unstemmed | Anterior Segment Imaging in Ocular Surface Squamous Neoplasia |
| title_short | Anterior Segment Imaging in Ocular Surface Squamous Neoplasia |
| title_sort | anterior segment imaging in ocular surface squamous neoplasia |
| url | http://dx.doi.org/10.1155/2016/5435092 |
| work_keys_str_mv | AT sallysong anteriorsegmentimaginginocularsurfacesquamousneoplasia AT gargikvora anteriorsegmentimaginginocularsurfacesquamousneoplasia AT preeyakgupta anteriorsegmentimaginginocularsurfacesquamousneoplasia |