Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade

Malformin C preferentially kills glioblastoma stem‐like cells via concerted induction of proteotoxic stress and autophagic flux blockade

Glioblastoma is a highly aggressive brain tumor for which there is no cure. The dire prognosis of this disease is largely attributable to a high level of heterogeneity, including the presence of a subpopulation of tumor‐initiating glioblastoma stem‐like cells (GSCs), which are refractory to chemo‐ a...

Full description

Saved in:
Bibliographic Details
Main Authors: Emma Phillips, Sizèd vanEnk, Sara Kildgaard, Silja Schlue, Mona Göttmann, Victoria Jennings, Frederic Bethke, Gabriele Müller, Christel Herold‐Mende, Daniel Pastor‐Flores, Martin Schneider, Dominic Helm, Thomas Ostenfeld Larsen, Violaine Goidts
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Molecular Oncology
Subjects:
autophagy
cancer
compound screen
glioblastoma
proteostasis
stem cells
Online Access:https://doi.org/10.1002/1878-0261.13756
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items