Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study
Abstract This prospective observational study aimed to investigate the effects of Ramadan fasting on serum lithium levels, renal function, and electrolyte balance in patients with bipolar disorder undergoing lithium maintenance therapy. Conducted in Saudi Arabia, a region characterized by hot and ar...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-05-01
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| Series: | International Journal of Bipolar Disorders |
| Online Access: | https://doi.org/10.1186/s40345-025-00378-7 |
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| author | Mohamed Abouzed Abdullah Saleh Altuhayni Salwa Rashed Alshammari Mohamed Saad Almuqahhwi Mohamed Elgernas Abdulkarim Almazyadi Abdullah Abdulaziz Alghuraymil Yousef Ibrahim Awwad Alenezy |
| author_facet | Mohamed Abouzed Abdullah Saleh Altuhayni Salwa Rashed Alshammari Mohamed Saad Almuqahhwi Mohamed Elgernas Abdulkarim Almazyadi Abdullah Abdulaziz Alghuraymil Yousef Ibrahim Awwad Alenezy |
| author_sort | Mohamed Abouzed |
| collection | DOAJ |
| description | Abstract This prospective observational study aimed to investigate the effects of Ramadan fasting on serum lithium levels, renal function, and electrolyte balance in patients with bipolar disorder undergoing lithium maintenance therapy. Conducted in Saudi Arabia, a region characterized by hot and arid climates (30–36 °C, 25% humidity during Ramadan 2024), the study included 250 participants divided into fasting (n = 131) and non-fasting (n = 119) groups. Serum lithium levels, renal function parameters (serum creatinine and estimated glomerular filtration rate), and electrolyte levels (sodium and potassium) were assessed at baseline, mid-Ramadan, one month post-Ramadan, and three months post-Ramadan. Statistical analyses included mixed-effects models, linear regression, and Wilcoxon rank-sum tests. The results indicate that Ramadan fasting did not significantly alter serum lithium levels, renal function, or electrolyte balance across all time points. These findings suggest that fasting during Ramadan can be safely practiced by patients with bipolar disorder receiving lithium therapy, provided they maintain adequate hydration and adhere to their prescribed medication regimen. |
| format | Article |
| id | doaj-art-0ec357d2501a4945810aa19636ca613c |
| institution | OA Journals |
| issn | 2194-7511 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj-art-0ec357d2501a4945810aa19636ca613c2025-08-20T02:32:00ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112025-05-011311710.1186/s40345-025-00378-7Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational studyMohamed Abouzed0Abdullah Saleh Altuhayni1Salwa Rashed Alshammari2Mohamed Saad Almuqahhwi3Mohamed Elgernas4Abdulkarim Almazyadi5Abdullah Abdulaziz Alghuraymil6Yousef Ibrahim7Awwad Alenezy8Psychiatry Department, Cairo Faculty of Medicine, Al-Azhar UniversityConsultant of Psychiatry, Erada Mental HospitalConsultant of Psychiatry, Erada Mental HospitalConsultant of Psychiatry, Erada Mental HospitalErada Mental HospitalPsychiatry resident, Erada Mental HospitalPsychiatry resident, Erada Mental HospitalPsychiatry Specialist, Erada Mental HospitalDepartment of Family and Community Medicine, Faculty of Medicine, Northern Border UniversityAbstract This prospective observational study aimed to investigate the effects of Ramadan fasting on serum lithium levels, renal function, and electrolyte balance in patients with bipolar disorder undergoing lithium maintenance therapy. Conducted in Saudi Arabia, a region characterized by hot and arid climates (30–36 °C, 25% humidity during Ramadan 2024), the study included 250 participants divided into fasting (n = 131) and non-fasting (n = 119) groups. Serum lithium levels, renal function parameters (serum creatinine and estimated glomerular filtration rate), and electrolyte levels (sodium and potassium) were assessed at baseline, mid-Ramadan, one month post-Ramadan, and three months post-Ramadan. Statistical analyses included mixed-effects models, linear regression, and Wilcoxon rank-sum tests. The results indicate that Ramadan fasting did not significantly alter serum lithium levels, renal function, or electrolyte balance across all time points. These findings suggest that fasting during Ramadan can be safely practiced by patients with bipolar disorder receiving lithium therapy, provided they maintain adequate hydration and adhere to their prescribed medication regimen.https://doi.org/10.1186/s40345-025-00378-7 |
| spellingShingle | Mohamed Abouzed Abdullah Saleh Altuhayni Salwa Rashed Alshammari Mohamed Saad Almuqahhwi Mohamed Elgernas Abdulkarim Almazyadi Abdullah Abdulaziz Alghuraymil Yousef Ibrahim Awwad Alenezy Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study International Journal of Bipolar Disorders |
| title | Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study |
| title_full | Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study |
| title_fullStr | Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study |
| title_full_unstemmed | Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study |
| title_short | Short-term and long-term effects of Muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder: a prospective observational study |
| title_sort | short term and long term effects of muslim fasting on lithium pharmacokinetics and renal function in bipolar disorder a prospective observational study |
| url | https://doi.org/10.1186/s40345-025-00378-7 |
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