Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection
A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopeni...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2016/6571621 |
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| _version_ | 1832567004471492608 |
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| author | Satoshi Suzuki Shihoko Nakajima Taiki Ando Keisuke Oda Manabu Sugita Kunimi Maeda Yutaka Nakiri Yoshinari Takasaki |
| author_facet | Satoshi Suzuki Shihoko Nakajima Taiki Ando Keisuke Oda Manabu Sugita Kunimi Maeda Yutaka Nakiri Yoshinari Takasaki |
| author_sort | Satoshi Suzuki |
| collection | DOAJ |
| description | A patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully controlled the SLE activity and improved the thrombocytopenia. An antecedent bacterial infection or SLE activity is believed to have contributed to the concurrent HIT. |
| format | Article |
| id | doaj-art-0ec2e6d67cba45a6948188a8b51c9873 |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-0ec2e6d67cba45a6948188a8b51c98732025-02-03T01:02:34ZengWileyCase Reports in Rheumatology2090-68892090-68972016-01-01201610.1155/2016/65716216571621Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial InfectionSatoshi Suzuki0Shihoko Nakajima1Taiki Ando2Keisuke Oda3Manabu Sugita4Kunimi Maeda5Yutaka Nakiri6Yoshinari Takasaki7Department of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo 113-8431, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Internal Medicine and Nephrology, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University Nerima Hospital, Tokyo 177-8521, JapanDepartment of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo 113-8431, JapanA patient with severe lupus nephritis developed thrombocytopenia during treatment with high-dose steroids. In addition to viral- or disease-induced cytopenia, the pathology was believed to arise from diverse contributing factors, such as thrombotic microangiopathy and heparin-related thrombocytopenia (HIT). By combining plasma exchange therapy and intravenous cyclophosphamide, we successfully controlled the SLE activity and improved the thrombocytopenia. An antecedent bacterial infection or SLE activity is believed to have contributed to the concurrent HIT.http://dx.doi.org/10.1155/2016/6571621 |
| spellingShingle | Satoshi Suzuki Shihoko Nakajima Taiki Ando Keisuke Oda Manabu Sugita Kunimi Maeda Yutaka Nakiri Yoshinari Takasaki Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection Case Reports in Rheumatology |
| title | Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection |
| title_full | Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection |
| title_fullStr | Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection |
| title_full_unstemmed | Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection |
| title_short | Heparin-Related Thrombocytopenia Triggered by Severe Status of Systemic Lupus Erythematosus and Bacterial Infection |
| title_sort | heparin related thrombocytopenia triggered by severe status of systemic lupus erythematosus and bacterial infection |
| url | http://dx.doi.org/10.1155/2016/6571621 |
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