Defining critical roles for NF‐κB p65 and type I interferon in innate immunity to rhinovirus

Defining critical roles for NF‐κB p65 and type I interferon in innate immunity to rhinovirus

Abstract The importance of NF‐κB activation and deficient anti‐viral interferon induction in the pathogenesis of rhinovirus‐induced asthma exacerbations is poorly understood. We provide the first in vivo evidence in man and mouse that rhinovirus infection enhanced bronchial epithelial cell NF‐κB p65...

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Bibliographic Details
Main Authors: Nathan W. Bartlett, Louise Slater, Nicholas Glanville, Jennifer J. Haas, Gaetano Caramori, Paolo Casolari, Deborah L. Clarke, Simon D. Message, Julia Aniscenko, Tatiana Kebadze, Jie Zhu, Patrick Mallia, Joseph P. Mizgerd, Maria Belvisi, Alberto Papi, Sergei V. Kotenko, Sebastian L. Johnston, Michael R. Edwards
Format: Article
Language:English
Published: Springer Nature 2012-11-01
Series:EMBO Molecular Medicine
Subjects:
asthma
inflammation
interferon
NF‐kappaB
rhinovirus
Online Access:https://doi.org/10.1002/emmm.201201650
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