Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis
The rapid global spread of Coronavirus Disease 2019 (COVID-19) has resulted in millions of infections and deaths, particularly impacting older adults. This study systematically analyzes risk factors reported in different geographical regions such as Asia and Europe that are associated with adverse o...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034124003666 |
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| author | Olunike Rebecca Abodunrin Mobolaji Timothy Olagunju Xinyi Huang Jianming Wang Zhibin Hu Chong Shen |
| author_facet | Olunike Rebecca Abodunrin Mobolaji Timothy Olagunju Xinyi Huang Jianming Wang Zhibin Hu Chong Shen |
| author_sort | Olunike Rebecca Abodunrin |
| collection | DOAJ |
| description | The rapid global spread of Coronavirus Disease 2019 (COVID-19) has resulted in millions of infections and deaths, particularly impacting older adults. This study systematically analyzes risk factors reported in different geographical regions such as Asia and Europe that are associated with adverse outcomes in older adults with COVID-19. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched five databases up to December 2023 and conducted meta-analyses of odds ratios for 27 risk factors reported in at least two studies using R software (version 4.3.2). Our meta-analysis identified 19 risk factors linked to adverse outcomes, with many of them common across regions, particularly in Asia and Europe. Key factors include old age (above 65 years), male gender, symptoms such as fever and dyspnea, and comorbidities like dementia, chronic obstructive pulmonary disease (COPD), chronic heart disease, hypertension, chronic kidney disease, and malnutrition. Laboratory biomarkers such as low oxygen saturation, thrombocytopenia, and elevated D-dimer were also associated with adverse outcomes. COVID-19 patients in Asia and Europe who are older adults, male, or have specific symptoms combined with underlying health conditions are at an increased risk of progressing to severe illness or mortality. |
| format | Article |
| id | doaj-art-0ec03eac713147f8ac35374d3ff9dfde |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-0ec03eac713147f8ac35374d3ff9dfde2025-01-21T04:12:57ZengElsevierJournal of Infection and Public Health1876-03412025-02-01182102632Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysisOlunike Rebecca Abodunrin0Mobolaji Timothy Olagunju1Xinyi Huang2Jianming Wang3Zhibin Hu4Chong Shen5Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaDepartment of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaCorrespondence to: Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning, Nanjing 211166, China; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, ChinaThe rapid global spread of Coronavirus Disease 2019 (COVID-19) has resulted in millions of infections and deaths, particularly impacting older adults. This study systematically analyzes risk factors reported in different geographical regions such as Asia and Europe that are associated with adverse outcomes in older adults with COVID-19. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched five databases up to December 2023 and conducted meta-analyses of odds ratios for 27 risk factors reported in at least two studies using R software (version 4.3.2). Our meta-analysis identified 19 risk factors linked to adverse outcomes, with many of them common across regions, particularly in Asia and Europe. Key factors include old age (above 65 years), male gender, symptoms such as fever and dyspnea, and comorbidities like dementia, chronic obstructive pulmonary disease (COPD), chronic heart disease, hypertension, chronic kidney disease, and malnutrition. Laboratory biomarkers such as low oxygen saturation, thrombocytopenia, and elevated D-dimer were also associated with adverse outcomes. COVID-19 patients in Asia and Europe who are older adults, male, or have specific symptoms combined with underlying health conditions are at an increased risk of progressing to severe illness or mortality.http://www.sciencedirect.com/science/article/pii/S1876034124003666COVID 19Adverse outcomeInfectious diseaseRisk factors, older adult |
| spellingShingle | Olunike Rebecca Abodunrin Mobolaji Timothy Olagunju Xinyi Huang Jianming Wang Zhibin Hu Chong Shen Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis Journal of Infection and Public Health COVID 19 Adverse outcome Infectious disease Risk factors, older adult |
| title | Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis |
| title_full | Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis |
| title_fullStr | Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis |
| title_full_unstemmed | Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis |
| title_short | Regional risk factors associated with adverse outcomes of COVID-19 infection among the older adult: A systematic review and meta-analysis |
| title_sort | regional risk factors associated with adverse outcomes of covid 19 infection among the older adult a systematic review and meta analysis |
| topic | COVID 19 Adverse outcome Infectious disease Risk factors, older adult |
| url | http://www.sciencedirect.com/science/article/pii/S1876034124003666 |
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