Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study
Abstract This study evaluated the adherence of bacteria, calcium, and magnesium to three different ureteral stents after endoscopic surgery for urinary calculi. We randomly assigned 61 patients requiring the insertion of ureteral stents after urinary calculi treatment into three groups: Percuflex wi...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-95095-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849392374144303104 |
|---|---|
| author | Shuzo Hamamoto Ryosuke Chaya Kazumi Taguchi Takaaki Inoue Shinsuke Okada Chatporn Boonyapalanant Masahiko Isogai Kengo Kawase Koei Torii Rei Unno Atsushi Okada Takahiro Yasui |
| author_facet | Shuzo Hamamoto Ryosuke Chaya Kazumi Taguchi Takaaki Inoue Shinsuke Okada Chatporn Boonyapalanant Masahiko Isogai Kengo Kawase Koei Torii Rei Unno Atsushi Okada Takahiro Yasui |
| author_sort | Shuzo Hamamoto |
| collection | DOAJ |
| description | Abstract This study evaluated the adherence of bacteria, calcium, and magnesium to three different ureteral stents after endoscopic surgery for urinary calculi. We randomly assigned 61 patients requiring the insertion of ureteral stents after urinary calculi treatment into three groups: Percuflex with a coating composition of Hydroplus (n = 21); Tria with a coating composition of Percushied (n = 22); and InLay Optima, which had a proprietary pHreeCoat coating (n = 18). All stents were removed and evaluated 1 month after treatment. The primary outcome was biomineral attachment to the ureteral stent. Calcium and magnesium contents were measured using atomic absorption spectrometry after the stent had been vortexed in a solution of saline and hydrochloric acid at pH 2. Bacteria were measured through flow cytometry of the washing solution collected by decantation after stent fragments had been immersed and vortexed in a saline solution. Median amounts of calcium and magnesium adhered to Percuflex were significantly higher than those adhered to Tria and InLay Optima. The median number of bacteria adhered was also highest in Percuflex compared to that in the other two groups, although without a statistically significant difference. These findings suggest that selecting stents with superior coating materials enhances patient outcomes and reduces stent-related complications. |
| format | Article |
| id | doaj-art-0ebdceca61b04bdd998e8b172368bbf5 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0ebdceca61b04bdd998e8b172368bbf52025-08-20T03:40:47ZengNature PortfolioScientific Reports2045-23222025-03-011511810.1038/s41598-025-95095-7Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind studyShuzo Hamamoto0Ryosuke Chaya1Kazumi Taguchi2Takaaki Inoue3Shinsuke Okada4Chatporn Boonyapalanant5Masahiko Isogai6Kengo Kawase7Koei Torii8Rei Unno9Atsushi Okada10Takahiro Yasui11Department of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Urology, Gamagori City HospitalDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Urology, Hara Genitourinary HospitalDepartment of Urology, Gyotoku General HospitalDivision of Urology, Department of Surgery, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot UniversityDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesDepartment of Nephro-urology, Nagoya City University Graduate School of Medical SciencesAbstract This study evaluated the adherence of bacteria, calcium, and magnesium to three different ureteral stents after endoscopic surgery for urinary calculi. We randomly assigned 61 patients requiring the insertion of ureteral stents after urinary calculi treatment into three groups: Percuflex with a coating composition of Hydroplus (n = 21); Tria with a coating composition of Percushied (n = 22); and InLay Optima, which had a proprietary pHreeCoat coating (n = 18). All stents were removed and evaluated 1 month after treatment. The primary outcome was biomineral attachment to the ureteral stent. Calcium and magnesium contents were measured using atomic absorption spectrometry after the stent had been vortexed in a solution of saline and hydrochloric acid at pH 2. Bacteria were measured through flow cytometry of the washing solution collected by decantation after stent fragments had been immersed and vortexed in a saline solution. Median amounts of calcium and magnesium adhered to Percuflex were significantly higher than those adhered to Tria and InLay Optima. The median number of bacteria adhered was also highest in Percuflex compared to that in the other two groups, although without a statistically significant difference. These findings suggest that selecting stents with superior coating materials enhances patient outcomes and reduces stent-related complications.https://doi.org/10.1038/s41598-025-95095-7Ureteral stent encrustationStent-related infectionsEndoscopic lithotripsyUrinary calculiBiomineral attachmentUSSQ |
| spellingShingle | Shuzo Hamamoto Ryosuke Chaya Kazumi Taguchi Takaaki Inoue Shinsuke Okada Chatporn Boonyapalanant Masahiko Isogai Kengo Kawase Koei Torii Rei Unno Atsushi Okada Takahiro Yasui Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study Scientific Reports Ureteral stent encrustation Stent-related infections Endoscopic lithotripsy Urinary calculi Biomineral attachment USSQ |
| title | Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study |
| title_full | Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study |
| title_fullStr | Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study |
| title_full_unstemmed | Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study |
| title_short | Ureteral stent biomaterial encrustation after endoscopic lithotripsy: a randomized, single-blind study |
| title_sort | ureteral stent biomaterial encrustation after endoscopic lithotripsy a randomized single blind study |
| topic | Ureteral stent encrustation Stent-related infections Endoscopic lithotripsy Urinary calculi Biomineral attachment USSQ |
| url | https://doi.org/10.1038/s41598-025-95095-7 |
| work_keys_str_mv | AT shuzohamamoto ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT ryosukechaya ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT kazumitaguchi ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT takaakiinoue ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT shinsukeokada ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT chatpornboonyapalanant ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT masahikoisogai ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT kengokawase ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT koeitorii ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT reiunno ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT atsushiokada ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy AT takahiroyasui ureteralstentbiomaterialencrustationafterendoscopiclithotripsyarandomizedsingleblindstudy |