Three-Compartment Pharmacokinetics of Inhaled and Injected Sinapine Thiocyanate Manifest Prolonged Retention and Its Therapeutics in Acute Lung Injury

Three-Compartment Pharmacokinetics of Inhaled and Injected Sinapine Thiocyanate Manifest Prolonged Retention and Its Therapeutics in Acute Lung Injury

<b>Background</b>: Acute lung injury (ALI) is driven by inflammatory cascades and reactive oxygen species (ROS) generation, with the progression to severe cases markedly increasing mortality. Sinapine thiocyanate (ST), a bioactive natural compound isolated from Sinapis Semen Albae (SSA),...

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Bibliographic Details
Main Authors:	Zixin Li, Caifen Wang, Huipeng Xu, Qian Wu, Ningning Peng, Lu Zhang, Hui Wang, Li Wu, Zegeng Li, Qinjun Yang, Jiwen Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2025-07-01
Series:	Pharmaceutics
Subjects:	sinapine thiocyanate dry powder inhaler pharmacokinetic acute lung injury MAPK signaling pathway
Online Access:	https://www.mdpi.com/1999-4923/17/7/909
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