The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus
Background: Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 <i>diabetes mellitus</i> (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metallopro...
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MDPI AG
2024-12-01
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| author | João Kleber de Almeida Gentile Renato Migliore Jaques Waisberg Marcelo Augusto Fontenelle Ribeiro Junior |
| author_facet | João Kleber de Almeida Gentile Renato Migliore Jaques Waisberg Marcelo Augusto Fontenelle Ribeiro Junior |
| author_sort | João Kleber de Almeida Gentile |
| collection | DOAJ |
| description | Background: Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 <i>diabetes mellitus</i> (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metalloproteinases (MMPs) play a key role in ECM regulation. The MMPs, particularly MMP-2 and MMP-9, are elevated in patients with morbid obesity, metabolic syndrome, and T2DM. Objectives: To evaluate the effect of weight loss in bariatric surgery patients using oxidative stress markers and to compare MMP levels in patients undergoing bariatric surgery. Methods: This was a prospective, controlled study including 45 morbidly obese patients with T2DM (BMI > 35 kg/m<sup>2</sup>) who underwent RYGB (n = 24) or VG (n = 21). Weight loss was assessed through anthropometric measurements (weight, height, BMI). MMP-2 and MMP-9 levels were measured preoperatively and at 3 and 12 months postoperatively. Results: Significant and sustained weight loss was observed after surgery in both groups, with reductions in BMI. MMP-2 and MMP-9 levels decreased significantly after one year of follow-up. Conclusions: Bariatric surgery is an effective long-term intervention for weight loss and associated comorbidities, including T2DM. MMP-2 and MMP-9 proved to be effective markers of extracellular matrix remodeling, with significant reductions following surgery. |
| format | Article |
| id | doaj-art-0ebccc0e2e694bf0840250c7158c508e |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj-art-0ebccc0e2e694bf0840250c7158c508e2025-08-20T02:01:00ZengMDPI AGBiomolecules2218-273X2024-12-011412163310.3390/biom14121633The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes MellitusJoão Kleber de Almeida Gentile0Renato Migliore1Jaques Waisberg2Marcelo Augusto Fontenelle Ribeiro Junior3Departament of Surgery, Institute of Infectology Emilio Ribas (IIER), São Paulo 01246-900, SP, BrazilDepartment of Surgery, Hospital São Camilo, São Paulo 02401-200, SP, BrazilDepartment of Surgery, ABC Medical School, Santo André 09060-870, SP, BrazilDepartment of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland, Baltimore, MD 21201, USABackground: Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 <i>diabetes mellitus</i> (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metalloproteinases (MMPs) play a key role in ECM regulation. The MMPs, particularly MMP-2 and MMP-9, are elevated in patients with morbid obesity, metabolic syndrome, and T2DM. Objectives: To evaluate the effect of weight loss in bariatric surgery patients using oxidative stress markers and to compare MMP levels in patients undergoing bariatric surgery. Methods: This was a prospective, controlled study including 45 morbidly obese patients with T2DM (BMI > 35 kg/m<sup>2</sup>) who underwent RYGB (n = 24) or VG (n = 21). Weight loss was assessed through anthropometric measurements (weight, height, BMI). MMP-2 and MMP-9 levels were measured preoperatively and at 3 and 12 months postoperatively. Results: Significant and sustained weight loss was observed after surgery in both groups, with reductions in BMI. MMP-2 and MMP-9 levels decreased significantly after one year of follow-up. Conclusions: Bariatric surgery is an effective long-term intervention for weight loss and associated comorbidities, including T2DM. MMP-2 and MMP-9 proved to be effective markers of extracellular matrix remodeling, with significant reductions following surgery.https://www.mdpi.com/2218-273X/14/12/1633bariatric surgerymorbid obesitymatrix metalloproteinasesgastric bypassgastroplastydiabetes mellitus |
| spellingShingle | João Kleber de Almeida Gentile Renato Migliore Jaques Waisberg Marcelo Augusto Fontenelle Ribeiro Junior The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus Biomolecules bariatric surgery morbid obesity matrix metalloproteinases gastric bypass gastroplasty diabetes mellitus |
| title | The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus |
| title_full | The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus |
| title_short | The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma Levels in Patients with Type 2 Diabetes Mellitus |
| title_sort | influence of bariatric surgery on matrix metalloproteinase plasma levels in patients with type 2 diabetes mellitus |
| topic | bariatric surgery morbid obesity matrix metalloproteinases gastric bypass gastroplasty diabetes mellitus |
| url | https://www.mdpi.com/2218-273X/14/12/1633 |
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