An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract
The sourcing of raw materials with low environmental impact, e.g., “upcycled” ingredients from short supply chains, has currently become necessary, and agri-food waste represents a very attractive hub to produce innovative cosmetic extracts. In this paper, an integrated approach considering all the...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/14/22/10603 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850149507349610496 |
|---|---|
| author | Marta Faggian Silvia Lucchetti Sara Ferrari Gabriele De Nadai Stefano Francescato Giovanni Baratto Nicola De Zordi Silvia-Maria Stanic Gregorio Peron Stefania Sut Alessandra Semenzato Stefano Dall’Acqua |
| author_facet | Marta Faggian Silvia Lucchetti Sara Ferrari Gabriele De Nadai Stefano Francescato Giovanni Baratto Nicola De Zordi Silvia-Maria Stanic Gregorio Peron Stefania Sut Alessandra Semenzato Stefano Dall’Acqua |
| author_sort | Marta Faggian |
| collection | DOAJ |
| description | The sourcing of raw materials with low environmental impact, e.g., “upcycled” ingredients from short supply chains, has currently become necessary, and agri-food waste represents a very attractive hub to produce innovative cosmetic extracts. In this paper, an integrated approach considering all the different steps, starting from material selection, extraction, chemical characterization, biological activity evaluation, and environmental impact calculation, was adopted to obtain innovative, sustainable, and effective cosmetic raw materials from food waste. As case report, a supercritical CO<sub>2</sub> extract obtained from wild-strawberry-processing waste after jam production (WSWSCO<sub>2</sub> extract) was developed. The fatty acids profile of the waste material and WSWSCO<sub>2</sub> extract was investigated via a GC–MS method, and mainly polyunsaturated fatty acids (PUFAs) such as linoleic and linolenic acids were detected. Furthermore, the ability of the WSWSCO<sub>2</sub> extract to inhibit 5α-reductase type 1 expression in skin fibroblasts was assessed, confirming significant efficacy at the dose of 5 mg/mL. Finally, in view of the eco-sustainability approach, the environmental impact related to WSWSCO<sub>2</sub> extract was calculated using a life cycle assessment (LCA) analytical approach, considering different parameters and indicators (e.g., carbon footprint) and verifying the eco-friendly approach in extract development and production. Although further research is needed, for example, to check the full composition of the extract and its effect on skin cells, these results suggest that the WSWSCO<sub>2</sub> extract may represent an innovative and sustainable ingredient for cosmetic applications especially in topical preparation for the treatment of some androgenic-related discomfort, such as acne and androgenic alopecia, reflecting the potentiality of the holistic and pioneering approach related to ingredient development presented in this study for the cosmetic sector. |
| format | Article |
| id | doaj-art-0ebbb782558d46c1bdbb152385ef0f71 |
| institution | OA Journals |
| issn | 2076-3417 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-0ebbb782558d46c1bdbb152385ef0f712025-08-20T02:26:54ZengMDPI AGApplied Sciences2076-34172024-11-0114221060310.3390/app142210603An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste ExtractMarta Faggian0Silvia Lucchetti1Sara Ferrari2Gabriele De Nadai3Stefano Francescato4Giovanni Baratto5Nicola De Zordi6Silvia-Maria Stanic7Gregorio Peron8Stefania Sut9Alessandra Semenzato10Stefano Dall’Acqua11Unired srl, Via Niccolò Tommaseo 69, 35131 Padova, ItalyUnired srl, Via Niccolò Tommaseo 69, 35131 Padova, ItalyUnifarco spa, Via Cal Longa 62, 32035 Belluno, ItalyUnifarco spa, Via Cal Longa 62, 32035 Belluno, ItalyUnifarco spa, Via Cal Longa 62, 32035 Belluno, ItalyUnifarco spa, Via Cal Longa 62, 32035 Belluno, ItalySocietà Agricola Moldoi—S.A.M srl, Loc. Maras Moldoi 151/a, 32037 Belluno, ItalyUnired srl, Via Niccolò Tommaseo 69, 35131 Padova, ItalyDepartment of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, ItalyUnired srl, Via Niccolò Tommaseo 69, 35131 Padova, ItalyThe sourcing of raw materials with low environmental impact, e.g., “upcycled” ingredients from short supply chains, has currently become necessary, and agri-food waste represents a very attractive hub to produce innovative cosmetic extracts. In this paper, an integrated approach considering all the different steps, starting from material selection, extraction, chemical characterization, biological activity evaluation, and environmental impact calculation, was adopted to obtain innovative, sustainable, and effective cosmetic raw materials from food waste. As case report, a supercritical CO<sub>2</sub> extract obtained from wild-strawberry-processing waste after jam production (WSWSCO<sub>2</sub> extract) was developed. The fatty acids profile of the waste material and WSWSCO<sub>2</sub> extract was investigated via a GC–MS method, and mainly polyunsaturated fatty acids (PUFAs) such as linoleic and linolenic acids were detected. Furthermore, the ability of the WSWSCO<sub>2</sub> extract to inhibit 5α-reductase type 1 expression in skin fibroblasts was assessed, confirming significant efficacy at the dose of 5 mg/mL. Finally, in view of the eco-sustainability approach, the environmental impact related to WSWSCO<sub>2</sub> extract was calculated using a life cycle assessment (LCA) analytical approach, considering different parameters and indicators (e.g., carbon footprint) and verifying the eco-friendly approach in extract development and production. Although further research is needed, for example, to check the full composition of the extract and its effect on skin cells, these results suggest that the WSWSCO<sub>2</sub> extract may represent an innovative and sustainable ingredient for cosmetic applications especially in topical preparation for the treatment of some androgenic-related discomfort, such as acne and androgenic alopecia, reflecting the potentiality of the holistic and pioneering approach related to ingredient development presented in this study for the cosmetic sector.https://www.mdpi.com/2076-3417/14/22/10603wild strawberryupcyclingsupercritical carbon dioxide (SCO<sub>2</sub>)5α-reductasecosmetic ingredient |
| spellingShingle | Marta Faggian Silvia Lucchetti Sara Ferrari Gabriele De Nadai Stefano Francescato Giovanni Baratto Nicola De Zordi Silvia-Maria Stanic Gregorio Peron Stefania Sut Alessandra Semenzato Stefano Dall’Acqua An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract Applied Sciences wild strawberry upcycling supercritical carbon dioxide (SCO<sub>2</sub>) 5α-reductase cosmetic ingredient |
| title | An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract |
| title_full | An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract |
| title_fullStr | An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract |
| title_full_unstemmed | An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract |
| title_short | An Integrated Approach to Develop Innovative, Sustainable, and Effective Cosmetic Ingredients: The Case Report of Fatty-Acids-Enriched Wild Strawberry Waste Extract |
| title_sort | integrated approach to develop innovative sustainable and effective cosmetic ingredients the case report of fatty acids enriched wild strawberry waste extract |
| topic | wild strawberry upcycling supercritical carbon dioxide (SCO<sub>2</sub>) 5α-reductase cosmetic ingredient |
| url | https://www.mdpi.com/2076-3417/14/22/10603 |
| work_keys_str_mv | AT martafaggian anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT silvialucchetti anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT saraferrari anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT gabrieledenadai anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefanofrancescato anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT giovannibaratto anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT nicoladezordi anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT silviamariastanic anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT gregorioperon anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefaniasut anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT alessandrasemenzato anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefanodallacqua anintegratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT martafaggian integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT silvialucchetti integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT saraferrari integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT gabrieledenadai integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefanofrancescato integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT giovannibaratto integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT nicoladezordi integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT silviamariastanic integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT gregorioperon integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefaniasut integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT alessandrasemenzato integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract AT stefanodallacqua integratedapproachtodevelopinnovativesustainableandeffectivecosmeticingredientsthecasereportoffattyacidsenrichedwildstrawberrywasteextract |