Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres
During pregnancy, primary <i>Toxoplasma gondii</i> infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages. This retrospective observational study (from 2007 to 2018...
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2025-02-01
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| author | Alice Bonetti Agnese Comelli Annacarla Chiesa Vania Spinoni Ambra Vola Federico Prefumo Adriana Valcamonico Carlo Bonfanti Silvio Caligaris Lina Rachele Tomasoni Fausto Baldanti Valeria Meroni |
| author_facet | Alice Bonetti Agnese Comelli Annacarla Chiesa Vania Spinoni Ambra Vola Federico Prefumo Adriana Valcamonico Carlo Bonfanti Silvio Caligaris Lina Rachele Tomasoni Fausto Baldanti Valeria Meroni |
| author_sort | Alice Bonetti |
| collection | DOAJ |
| description | During pregnancy, primary <i>Toxoplasma gondii</i> infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages. This retrospective observational study (from 2007 to 2018) was conducted in two Italian referral hospitals: Fondazione IRCCS Policlinico San Matteo in Pavia and Spedali Civili in Brescia. In total, 247 pregnant women were enrolled: seroconversions were enrolled: seroconversions documented as having occurred in the two months preceding pregnancy in 12 cases (4.9%; 95% CI 2.2–7.5%), and during pregnancy in 235 cases (95.1%; 95% CI 92.5–97.8%). SC is defined as the appearance of specific anti-Toxoplasma antibodies (IgM/IgG) during pregnancy in a previously seronegative woman. A total of 56 (22.5%; 95% CI 17.3–27.7%) newborns were lost to follow-up; thus, the outcome of 193 (77.5%; 95% CI 72.3–82.7%) newborns was analyzed. The overall transmission rate of <i>T. gondii</i> infection was 23.8% (95% CI 17.8–29.8%), 0% (95% CI 0.0–11.9%) among the 1st trimester SCs, 12.5% (95% CI 5.6–19.4%) among the 2nd trimester SCs, 53.8% (95% CI 41.7–66.0%) among the 3rd trimester ones. No CT were found in the group of periconceptional infection. Among the infected newborns, clinically manifest cases were 12 (26.1%; 95% CI 13.4–38.8%), including 1 case (2.2%; 95% CI 2.0–6.4%) of stillbirth and 11 symptomatic neonates (23.9%; 95% CI 11.6–36.2%). A total of 83 amniocentesis were performed (33.6%; 95% CI 27.7–39.5%), no complication was recorded and no false positive or false negative results were registered. The results are in line with the fetal risks reported in literature for <i>T. gondii</i> infection during pregnancy, even if at a lower percentage probably due to a prompt treatment. |
| format | Article |
| id | doaj-art-0ebb025a47b3407db30489f6d64abea2 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-0ebb025a47b3407db30489f6d64abea22025-08-20T02:03:32ZengMDPI AGPathogens2076-08172025-02-0114215710.3390/pathogens14020157Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral CentresAlice Bonetti0Agnese Comelli1Annacarla Chiesa2Vania Spinoni3Ambra Vola4Federico Prefumo5Adriana Valcamonico6Carlo Bonfanti7Silvio Caligaris8Lina Rachele Tomasoni9Fausto Baldanti10Valeria Meroni11Microbiology and Virology Unit, Diagnostic Medicine Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyInfectious Diseases Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDepartment of Infectious Diseases, Manzoni Hospital, 23900 Lecco, ItalyDepartment of Neonatology and Neonatal Intensive Care, Spedali Civili Hospital, Spedali Civili, 25123 Brescia, ItalyMicrobiology and Virology Unit, Diagnostic Medicine Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyObstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genova, ItalyDepartment of Obstetrics and Gynecology, University of Brescia, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Infectious and Tropical Diseases, ASST Spedali Civili, 25123 Brescia, ItalyMicrobiology and Virology Unit, Diagnostic Medicine Department, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, ItalyDepartment of Molecular Medicine, University of Pavia, 27100 Pavia, ItalyDuring pregnancy, primary <i>Toxoplasma gondii</i> infection can cause congenital toxoplasmosis (CT). We described the newborns’ outcomes from a multicentre cohort of mothers with seroconversion (SC) at different gestational ages. This retrospective observational study (from 2007 to 2018) was conducted in two Italian referral hospitals: Fondazione IRCCS Policlinico San Matteo in Pavia and Spedali Civili in Brescia. In total, 247 pregnant women were enrolled: seroconversions were enrolled: seroconversions documented as having occurred in the two months preceding pregnancy in 12 cases (4.9%; 95% CI 2.2–7.5%), and during pregnancy in 235 cases (95.1%; 95% CI 92.5–97.8%). SC is defined as the appearance of specific anti-Toxoplasma antibodies (IgM/IgG) during pregnancy in a previously seronegative woman. A total of 56 (22.5%; 95% CI 17.3–27.7%) newborns were lost to follow-up; thus, the outcome of 193 (77.5%; 95% CI 72.3–82.7%) newborns was analyzed. The overall transmission rate of <i>T. gondii</i> infection was 23.8% (95% CI 17.8–29.8%), 0% (95% CI 0.0–11.9%) among the 1st trimester SCs, 12.5% (95% CI 5.6–19.4%) among the 2nd trimester SCs, 53.8% (95% CI 41.7–66.0%) among the 3rd trimester ones. No CT were found in the group of periconceptional infection. Among the infected newborns, clinically manifest cases were 12 (26.1%; 95% CI 13.4–38.8%), including 1 case (2.2%; 95% CI 2.0–6.4%) of stillbirth and 11 symptomatic neonates (23.9%; 95% CI 11.6–36.2%). A total of 83 amniocentesis were performed (33.6%; 95% CI 27.7–39.5%), no complication was recorded and no false positive or false negative results were registered. The results are in line with the fetal risks reported in literature for <i>T. gondii</i> infection during pregnancy, even if at a lower percentage probably due to a prompt treatment.https://www.mdpi.com/2076-0817/14/2/157toxoplasmosis in pregnancy<i>Toxoplasma gondii</i>amniocentesisspiramycinpyrimethaminesulfadiazine |
| spellingShingle | Alice Bonetti Agnese Comelli Annacarla Chiesa Vania Spinoni Ambra Vola Federico Prefumo Adriana Valcamonico Carlo Bonfanti Silvio Caligaris Lina Rachele Tomasoni Fausto Baldanti Valeria Meroni Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres Pathogens toxoplasmosis in pregnancy <i>Toxoplasma gondii</i> amniocentesis spiramycin pyrimethamine sulfadiazine |
| title | Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres |
| title_full | Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres |
| title_fullStr | Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres |
| title_full_unstemmed | Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres |
| title_short | Risk of Congenital Toxoplasmosis in Newborns from Mothers with Documented Infection: Experience from Two Referral Centres |
| title_sort | risk of congenital toxoplasmosis in newborns from mothers with documented infection experience from two referral centres |
| topic | toxoplasmosis in pregnancy <i>Toxoplasma gondii</i> amniocentesis spiramycin pyrimethamine sulfadiazine |
| url | https://www.mdpi.com/2076-0817/14/2/157 |
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