Lactylation: a promising therapeutic target in ischemia-reperfusion injury management
Abstract Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such injury. Lactylation, a newly discovered po...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-03-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02381-4 |
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| author | Fei-xiang Wang Guo Mu Zi-hang Yu Zu-an Shi Xue-xin Li Xin Fan Ye Chen Jun Zhou |
| author_facet | Fei-xiang Wang Guo Mu Zi-hang Yu Zu-an Shi Xue-xin Li Xin Fan Ye Chen Jun Zhou |
| author_sort | Fei-xiang Wang |
| collection | DOAJ |
| description | Abstract Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such injury. Lactylation, a newly discovered post-translational modification in 2019, is induced by lactic acid and predominantly occurs on lysine residues of histone or nonhistone proteins. Extensive studies have demonstrated the pivotal role of lactylation in the pathogenesis and progression of various diseases, including melanoma, myocardial infarction, hepatocellular carcinoma, Alzheimer’s disease, and nonalcoholic fatty liver disease. Additionally, a marked correlation between lactylation and inflammation has been observed. This article provides a comprehensive review of the mechanism underlying lactylation in IRI to establish a theoretical foundation for better understanding the interplay between lactylation and IRI. |
| format | Article |
| id | doaj-art-0eba87de403f43618bb3cfe38973a649 |
| institution | DOAJ |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-0eba87de403f43618bb3cfe38973a6492025-08-20T02:56:09ZengNature Publishing GroupCell Death Discovery2058-77162025-03-0111111710.1038/s41420-025-02381-4Lactylation: a promising therapeutic target in ischemia-reperfusion injury managementFei-xiang Wang0Guo Mu1Zi-hang Yu2Zu-an Shi3Xue-xin Li4Xin Fan5Ye Chen6Jun Zhou7Department of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Anesthesiology, Fushun County People’s HospitalDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityDepartment of Traditional Chinese Medicine, The Affiliated Hospital, Southwest Medical UniversityDepartment of Anesthesiology, The Affiliated Hospital, Southwest Medical UniversityAbstract Ischemia-reperfusion injury (IRI) is a critical condition that poses a significant threat to patient safety. The production of lactate increases during the process of IRI, and lactate serves as a crucial indicator for assessing the severity of such injury. Lactylation, a newly discovered post-translational modification in 2019, is induced by lactic acid and predominantly occurs on lysine residues of histone or nonhistone proteins. Extensive studies have demonstrated the pivotal role of lactylation in the pathogenesis and progression of various diseases, including melanoma, myocardial infarction, hepatocellular carcinoma, Alzheimer’s disease, and nonalcoholic fatty liver disease. Additionally, a marked correlation between lactylation and inflammation has been observed. This article provides a comprehensive review of the mechanism underlying lactylation in IRI to establish a theoretical foundation for better understanding the interplay between lactylation and IRI.https://doi.org/10.1038/s41420-025-02381-4 |
| spellingShingle | Fei-xiang Wang Guo Mu Zi-hang Yu Zu-an Shi Xue-xin Li Xin Fan Ye Chen Jun Zhou Lactylation: a promising therapeutic target in ischemia-reperfusion injury management Cell Death Discovery |
| title | Lactylation: a promising therapeutic target in ischemia-reperfusion injury management |
| title_full | Lactylation: a promising therapeutic target in ischemia-reperfusion injury management |
| title_fullStr | Lactylation: a promising therapeutic target in ischemia-reperfusion injury management |
| title_full_unstemmed | Lactylation: a promising therapeutic target in ischemia-reperfusion injury management |
| title_short | Lactylation: a promising therapeutic target in ischemia-reperfusion injury management |
| title_sort | lactylation a promising therapeutic target in ischemia reperfusion injury management |
| url | https://doi.org/10.1038/s41420-025-02381-4 |
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