Comparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: a prospective randomized controlled trial

Comparison of utilizing a hypertonic saline solution and mannitol to improve brain relaxation during craniotomy in patients with brain tumours: a prospective randomized controlled trial

Abstract Hyperosmolar therapy, specifically the use of mannitol, has been employed to improve brain relaxation, but mannitol use may cause hypovolemia and electrolyte imbalance. Given these risks, hypertonic saline was introduced as an alternative; however, data on its efficacy and safety are limite...

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Main Authors: Cattleya Thongrong, Worapoom Tangphikunatam, Pornthep Kasemsiri, Pichayen Duangthongphon, Amnat Kitkhuandee, Narin Plailaharn, Apinya Kittiponghansa, Darunee Sripadungkul, Monsicha Somjit, Lumyai Sabangban, Thirada Jimarsa
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Brain relaxation
Mannitol
Hypertonic saline
Hyperosmolar therapy
Online Access:https://doi.org/10.1038/s41598-025-15002-y
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