TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury

TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury

BackgroundTraumatic brain injury (TBI) triggers a cascade of neuroinflammatory responses mediated by microglial activation, which significantly contributes to secondary brain damage. While triggering receptor expressed on myeloid cells-1 (TREM-1) is a key inflammatory amplifier, its mechanistic role...

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Bibliographic Details
Main Authors: Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Chuanpeng Zhang, Kun He, Xu Yang, Zixi Wang, Li Zhang, Yanbing Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
traumatic brain injury
TREM-1
neuroinflammation
pyroptosis
NF-κB signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1636917/full
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