Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women

Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women

BackgroundPregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints. Current preclinical models, including animal studies, fail to accurate...

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Main Authors: Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Christian Maass
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
pregnancy
organ-on-chip
computational modelling
pharmacokinetics
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1528748/full
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