Chaperone-mediated autophagy in fish: A key function amid a changing environment
Chaperone-Mediated Autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homoeostasis and metabolism. While extensively studied in mammals, CMA’s existence in fish has only been confirmed recently, offering exciting insights into its role in species facing environmental s...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Autophagy Reports |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/27694127.2024.2403956 |
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| author | Simon Schnebert Emilio J Vélez Maxime Goguet Karine Dias Vincent Véron Isabel García-Pérez Lisa M Radler Emilie Cardona Stéphanie Fontagné-Dicharry Pierre Van Delft Franziska Dittrich-Domergue Amélie Bernard Florian Beaumatin Amaury Herpin Beth Cleveland Iban Seiliez |
| author_facet | Simon Schnebert Emilio J Vélez Maxime Goguet Karine Dias Vincent Véron Isabel García-Pérez Lisa M Radler Emilie Cardona Stéphanie Fontagné-Dicharry Pierre Van Delft Franziska Dittrich-Domergue Amélie Bernard Florian Beaumatin Amaury Herpin Beth Cleveland Iban Seiliez |
| author_sort | Simon Schnebert |
| collection | DOAJ |
| description | Chaperone-Mediated Autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homoeostasis and metabolism. While extensively studied in mammals, CMA’s existence in fish has only been confirmed recently, offering exciting insights into its role in species facing environmental stress. Here, we shed light on the existence of 2 genes encoding the CMA-limiting factor Lamp2A (lysosomal associated membrane protein 2A) in rainbow trout (RT, Oncorhynchus mykiss), revealing distinct expression patterns across various tissues. Notably, RT lacking the most expressed Lamp2A exhibit profound hepatic proteome disturbances during acute nutritional stress, underscoring its pivotal role as a guardian of hepatic proteostasis. Building upon these findings, we introduce and validate the CMA activation score as a reliable indicator of CMA status, providing a valuable tool for detecting cellular stress in fish under environmental threats. Overall, our study offers new perspectives into understanding CMA from evolutionary and environmental contexts. |
| format | Article |
| id | doaj-art-0eae5580c50f4e10ad5ee5490cf10351 |
| institution | OA Journals |
| issn | 2769-4127 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj-art-0eae5580c50f4e10ad5ee5490cf103512025-08-20T02:30:42ZengTaylor & Francis GroupAutophagy Reports2769-41272024-12-013110.1080/27694127.2024.2403956Chaperone-mediated autophagy in fish: A key function amid a changing environmentSimon Schnebert0Emilio J Vélez1Maxime Goguet2Karine Dias3Vincent Véron4Isabel García-Pérez5Lisa M Radler6Emilie Cardona7Stéphanie Fontagné-Dicharry8Pierre Van Delft9Franziska Dittrich-Domergue10Amélie Bernard11Florian Beaumatin12Amaury Herpin13Beth Cleveland14Iban Seiliez15Université de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceNational Center for Cool and Cold Water Aquaculture, ARS/USDA, Kearneysville, WV, USAUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceLaboratoire de Biogenèse Membranaire, UMR, CNRS, Univ. Bordeaux, Villenave d’Ornon, FranceLaboratoire de Biogenèse Membranaire, UMR, CNRS, Univ. Bordeaux, Villenave d’Ornon, FranceLaboratoire de Biogenèse Membranaire, UMR, CNRS, Univ. Bordeaux, Villenave d’Ornon, FranceUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceINRAE, UR Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, Rennes, FranceNational Center for Cool and Cold Water Aquaculture, ARS/USDA, Kearneysville, WV, USAUniversité de Pau et des Pays de l’Adour, E2S UPPA, INRAE, Nutrition Métabolisme et Aquaculture, NuMeA, Saint-Pée-sur Nivelle, FranceChaperone-Mediated Autophagy (CMA) is a major pathway of lysosomal proteolysis critical for cellular homoeostasis and metabolism. While extensively studied in mammals, CMA’s existence in fish has only been confirmed recently, offering exciting insights into its role in species facing environmental stress. Here, we shed light on the existence of 2 genes encoding the CMA-limiting factor Lamp2A (lysosomal associated membrane protein 2A) in rainbow trout (RT, Oncorhynchus mykiss), revealing distinct expression patterns across various tissues. Notably, RT lacking the most expressed Lamp2A exhibit profound hepatic proteome disturbances during acute nutritional stress, underscoring its pivotal role as a guardian of hepatic proteostasis. Building upon these findings, we introduce and validate the CMA activation score as a reliable indicator of CMA status, providing a valuable tool for detecting cellular stress in fish under environmental threats. Overall, our study offers new perspectives into understanding CMA from evolutionary and environmental contexts.https://www.tandfonline.com/doi/10.1080/27694127.2024.2403956Chaperone-mediated autophagyfishrainbow troutmetabolismstressenvironment |
| spellingShingle | Simon Schnebert Emilio J Vélez Maxime Goguet Karine Dias Vincent Véron Isabel García-Pérez Lisa M Radler Emilie Cardona Stéphanie Fontagné-Dicharry Pierre Van Delft Franziska Dittrich-Domergue Amélie Bernard Florian Beaumatin Amaury Herpin Beth Cleveland Iban Seiliez Chaperone-mediated autophagy in fish: A key function amid a changing environment Autophagy Reports Chaperone-mediated autophagy fish rainbow trout metabolism stress environment |
| title | Chaperone-mediated autophagy in fish: A key function amid a changing environment |
| title_full | Chaperone-mediated autophagy in fish: A key function amid a changing environment |
| title_fullStr | Chaperone-mediated autophagy in fish: A key function amid a changing environment |
| title_full_unstemmed | Chaperone-mediated autophagy in fish: A key function amid a changing environment |
| title_short | Chaperone-mediated autophagy in fish: A key function amid a changing environment |
| title_sort | chaperone mediated autophagy in fish a key function amid a changing environment |
| topic | Chaperone-mediated autophagy fish rainbow trout metabolism stress environment |
| url | https://www.tandfonline.com/doi/10.1080/27694127.2024.2403956 |
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