A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes
Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies.
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2009-0489 |
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| author | D. A. M. Heideman F. B. Thunnissen M. Doeleman D. Kramer H. M. Verheul E. F. Smit P. E. Postmus C. J. L. M. Meijer G.A. Meijer P. J. F. Snijders |
| author_facet | D. A. M. Heideman F. B. Thunnissen M. Doeleman D. Kramer H. M. Verheul E. F. Smit P. E. Postmus C. J. L. M. Meijer G.A. Meijer P. J. F. Snijders |
| author_sort | D. A. M. Heideman |
| collection | DOAJ |
| description | Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies. |
| format | Article |
| id | doaj-art-0ea96d7979ce4bb1a0a7eaa416f018b2 |
| institution | OA Journals |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-0ea96d7979ce4bb1a0a7eaa416f018b22025-08-20T02:02:37ZengWileyCellular Oncology1570-58701875-86062009-01-0131532933310.3233/CLO-2009-0489A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras GenesD. A. M. Heideman0F. B. Thunnissen1M. Doeleman2D. Kramer3H. M. Verheul4E. F. Smit5P. E. Postmus6C. J. L. M. Meijer7G.A. Meijer8P. J. F. Snijders9Department of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Medical Oncology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pulmonary Diseases, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsDepartment of Pathology, VU University Medical Center, Amsterdam, The NetherlandsBackground: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use of EGFR-targeted therapies.http://dx.doi.org/10.3233/CLO-2009-0489 |
| spellingShingle | D. A. M. Heideman F. B. Thunnissen M. Doeleman D. Kramer H. M. Verheul E. F. Smit P. E. Postmus C. J. L. M. Meijer G.A. Meijer P. J. F. Snijders A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes Cellular Oncology |
| title | A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes |
| title_full | A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes |
| title_fullStr | A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes |
| title_full_unstemmed | A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes |
| title_short | A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes |
| title_sort | panel of high resolution melting hrm technology based assays with direct sequencing possibility for effective mutation screening of egfr and k ras genes |
| url | http://dx.doi.org/10.3233/CLO-2009-0489 |
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