Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

Clinical and molecular implications of cGAS/STING signaling in checkpoint inhibitor immunotherapy

Recent studies reported that cytoplasmic dsDNA-induced activation of cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) signaling has tremendous potential for antitumor immunity by inducing the production of type I Interferon (IFN), resulting in activation of both innate and adapt...

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Bibliographic Details
Main Authors: Hao Chen, Yang Zhong, Rongjie Feng, Xingyu Zhu, Kang Xu, Mingjie Kuang, Wei Chong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
cGAS/STING
checkpoint inhibitors therapy
tumor immunogenomics
predictive marker
CPI
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1556736/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1556736/full

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