Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1
Introduction: Infection of pathogenic microorganisms is an important reason for autoimmune diseases (ADs). Interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK1) is a key mediator in infection immunity, while the gene of IRAK1 is recognized as a risk gene in ADs. Three single nucleotide polymorph...
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The Journal of Infection in Developing Countries
2015-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/6776 |
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| author | Changzheng Li Shaohui Huang Sunlian Mo Ning Zhang Liang Zhou Zhi Mao Weiran Lv Juan Li Ye Zhou |
| author_facet | Changzheng Li Shaohui Huang Sunlian Mo Ning Zhang Liang Zhou Zhi Mao Weiran Lv Juan Li Ye Zhou |
| author_sort | Changzheng Li |
| collection | DOAJ |
| description | Introduction: Infection of pathogenic microorganisms is an important reason for autoimmune diseases (ADs). Interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK1) is a key mediator in infection immunity, while the gene of IRAK1 is recognized as a risk gene in ADs. Three single nucleotide polymorphisms (SNPs) in IRAK1 (rs3027898, rs1059702, rs1059703) are considered to be associated with ADs risk. However, the results are conflicting. We conducted this study to get more precise estimations.
Methodology: PubMed, OvidSP, and CNKI databases (published prior to August 2014) were searched, and data was extracted from eligible studies. The procedure of statistical analysis was performed using STATA 12.0 software. A random effect model or fixed effect model was chosen based on the between-study heterogeneities.
Results: Of the studies involved, 11 studies included 10,705 cases (9,865 controls) for rs3027898, 9 studies included 15,005 cases (14,997 controls) for rs1059702, and 7 studies included 8,115 cases (6,815 controls) for rs1059703. Overall, the results showed that there were significant associations with ADs risk in three genetic models for rs3027898 and in four genetic models for rs1059702, but in neither model for rs1059703. Moreover, in stratified analyses, different extents of associations were found in some different genetic models for all three SNPs.
Conclusion: Our data demonstrated that these three SNPs (rs3027898, rs1059702, rs1059703) in IRAK1 were associated with ADs risk.
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| format | Article |
| id | doaj-art-0ea54e0927c24728b1cff1bc7dc5586f |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0ea54e0927c24728b1cff1bc7dc5586f2025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-07-0190610.3855/jidc.6776Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1Changzheng Li0Shaohui Huang1Sunlian Mo2Ning Zhang3Liang Zhou4Zhi Mao5Weiran Lv6Juan Li7Ye Zhou8Nanfang Hospital, Southern Medical University, Guangzhou, ChinaSouthern Medical University, Guangzhou, ChinaNanfang Hospital, Southern Medical University, Guangzhou, ChinaShandong University of Traditional Chinese Medicine, Jinan, ChinaVirginia Commonwealth University and Massey Cancer Center, Richmond, Virginia, United StatesChinese PLA General Hospital, Beijing, ChinaNanfang Hospital, Southern Medical University, Guangzhou, ChinaNanfang Hospital, Southern Medical University, Guangzhou, ChinaSchool of Biotechnology, Southern Medical University, Guangzhou, ChinaIntroduction: Infection of pathogenic microorganisms is an important reason for autoimmune diseases (ADs). Interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK1) is a key mediator in infection immunity, while the gene of IRAK1 is recognized as a risk gene in ADs. Three single nucleotide polymorphisms (SNPs) in IRAK1 (rs3027898, rs1059702, rs1059703) are considered to be associated with ADs risk. However, the results are conflicting. We conducted this study to get more precise estimations. Methodology: PubMed, OvidSP, and CNKI databases (published prior to August 2014) were searched, and data was extracted from eligible studies. The procedure of statistical analysis was performed using STATA 12.0 software. A random effect model or fixed effect model was chosen based on the between-study heterogeneities. Results: Of the studies involved, 11 studies included 10,705 cases (9,865 controls) for rs3027898, 9 studies included 15,005 cases (14,997 controls) for rs1059702, and 7 studies included 8,115 cases (6,815 controls) for rs1059703. Overall, the results showed that there were significant associations with ADs risk in three genetic models for rs3027898 and in four genetic models for rs1059702, but in neither model for rs1059703. Moreover, in stratified analyses, different extents of associations were found in some different genetic models for all three SNPs. Conclusion: Our data demonstrated that these three SNPs (rs3027898, rs1059702, rs1059703) in IRAK1 were associated with ADs risk. https://jidc.org/index.php/journal/article/view/6776autoimmune diseasessusceptibilityinterleukin-1 receptor-associated kinase-1single nucleotide polymorphisms |
| spellingShingle | Changzheng Li Shaohui Huang Sunlian Mo Ning Zhang Liang Zhou Zhi Mao Weiran Lv Juan Li Ye Zhou Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 Journal of Infection in Developing Countries autoimmune diseases susceptibility interleukin-1 receptor-associated kinase-1 single nucleotide polymorphisms |
| title | Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 |
| title_full | Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 |
| title_fullStr | Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 |
| title_full_unstemmed | Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 |
| title_short | Susceptibility of autoimmune diseases in three polymorphisms of infection-associated gene IRAK1 |
| title_sort | susceptibility of autoimmune diseases in three polymorphisms of infection associated gene irak1 |
| topic | autoimmune diseases susceptibility interleukin-1 receptor-associated kinase-1 single nucleotide polymorphisms |
| url | https://jidc.org/index.php/journal/article/view/6776 |
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