Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy
We investigated the effect of center-specific variables on overall survival (OS) after allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML). Eligible were adult patients reported to DRST registry receiving first alloHCT for AML from a related or matched (>= 9/1...
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Ferrata Storti Foundation
2024-12-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/11863 |
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| author | Wolfgang Bethge Sarah Flossdorf Franziska Hanke Christoph Schmid Mark Ringhoffer Stefan Klein Bernd Hertenstein Johannes Schetelig Matthias Stelljes Thomas Schroeder Igor Wolfgang Blau Francis Ayuk Matthias Eder Robert Zeiser Katharina Fleischhauer Nicolaus Kröger Peter Dreger |
| author_facet | Wolfgang Bethge Sarah Flossdorf Franziska Hanke Christoph Schmid Mark Ringhoffer Stefan Klein Bernd Hertenstein Johannes Schetelig Matthias Stelljes Thomas Schroeder Igor Wolfgang Blau Francis Ayuk Matthias Eder Robert Zeiser Katharina Fleischhauer Nicolaus Kröger Peter Dreger |
| author_sort | Wolfgang Bethge |
| collection | DOAJ |
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We investigated the effect of center-specific variables on overall survival (OS) after allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML). Eligible were adult patients reported to DRST registry receiving first alloHCT for AML from a related or matched (>= 9/10 HLA-match) unrelated donor 2015-2021. Primary endpoint was OS at 12 months from alloHCT. Univariable and multivariable analyses after best subset selection was performed. Of 5328 patients, 83% received alloHCT in a high-volume center (≥40 alloHCT/year); 90% in a university hospital; 90% in a center performing alloHCT for ≥10 years; and 73% in a Joint Accreditation Committee IHCT-Europe and EBMT (JACIE) accredited center. 52% of the patients were in CR1, and ELN risk was adverse in 37% and intermediate in 42%. On multivariable analysis, center-specific factors predicting adverse 12-month OS were program duration |
| format | Article |
| id | doaj-art-0ea4f949fd484868b276ead1bf532166 |
| institution | OA Journals |
| issn | 0390-6078 1592-8721 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Ferrata Storti Foundation |
| record_format | Article |
| series | Haematologica |
| spelling | doaj-art-0ea4f949fd484868b276ead1bf5321662025-08-20T02:19:37ZengFerrata Storti FoundationHaematologica0390-60781592-87212024-12-01999110.3324/haematol.2024.286385Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell TherapyWolfgang Bethge0Sarah Flossdorf1Franziska Hanke2Christoph Schmid3Mark Ringhoffer4Stefan Klein5Bernd Hertenstein6Johannes Schetelig7Matthias Stelljes8Thomas Schroeder9Igor Wolfgang Blau10Francis Ayuk11Matthias Eder12Robert Zeiser13Katharina Fleischhauer14Nicolaus Kröger15Peter Dreger16University Hospital Tuebingen, Tuebingen, Germany; German Working Group for Hematopoietic Stem Cell Transplantation and Cellular TherapyInstitute for Medical Informatics, Biometry, and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany; German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy, UlmGerman Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy, UlmUniversity Hospital Augsburg, AugsburgHospital Karlsruhe, KarlsruheUniversity Hospital Mannheim, MannheimCentral Hospital Bremen, BremenGerman Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy; University Hospital Dresden, DresdenGerman Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy; University Hospital Muenster, MuensterUniversity Hospital Essen, EssenUniversity Hospital Charité Berlin, BerlinGerman Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy; University Medical Center Hamburg, HamburgUniversity Hospital Hannover, HannoverUniversity Hospital Freiburg, FreiburgGerman Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy, Ulm, Germany; University Hospital Essen, EssenGerman Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy, Ulm, Germany; University Medical Center Hamburg, HamburgGerman Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy; University Hospital Heidelberg, Heidelberg We investigated the effect of center-specific variables on overall survival (OS) after allogeneic hematopoietic cell transplantation (alloHCT) in acute myeloid leukemia (AML). Eligible were adult patients reported to DRST registry receiving first alloHCT for AML from a related or matched (>= 9/10 HLA-match) unrelated donor 2015-2021. Primary endpoint was OS at 12 months from alloHCT. Univariable and multivariable analyses after best subset selection was performed. Of 5328 patients, 83% received alloHCT in a high-volume center (≥40 alloHCT/year); 90% in a university hospital; 90% in a center performing alloHCT for ≥10 years; and 73% in a Joint Accreditation Committee IHCT-Europe and EBMT (JACIE) accredited center. 52% of the patients were in CR1, and ELN risk was adverse in 37% and intermediate in 42%. On multivariable analysis, center-specific factors predicting adverse 12-month OS were program duration https://haematologica.org/article/view/11863 |
| spellingShingle | Wolfgang Bethge Sarah Flossdorf Franziska Hanke Christoph Schmid Mark Ringhoffer Stefan Klein Bernd Hertenstein Johannes Schetelig Matthias Stelljes Thomas Schroeder Igor Wolfgang Blau Francis Ayuk Matthias Eder Robert Zeiser Katharina Fleischhauer Nicolaus Kröger Peter Dreger Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy Haematologica |
| title | Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy |
| title_full | Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy |
| title_fullStr | Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy |
| title_full_unstemmed | Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy |
| title_short | Does size matter? Center-specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia: an analysis of the German Registry for Stem Cell Transplantation and Cell Therapy |
| title_sort | does size matter center specific characteristics and survival after allogeneic hematopoietic cell transplantation for acute myeloid leukemia an analysis of the german registry for stem cell transplantation and cell therapy |
| url | https://haematologica.org/article/view/11863 |
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