β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

Abstract Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavi...

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Main Authors: Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Traumatic brain injury
Neuroinflammation
β2 integrin
Neutrophil extracellular traps
Intercellular adhesion molecule-1
Online Access:https://doi.org/10.1186/s12964-025-02071-9
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