Bacteriophages and their potential for treatment of metabolic diseases
Abstract Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart disease, and hyperlipi...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70024 |
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| author | Youpeng Deng Shouwei Jiang Hanyu Duan Haonan Shao Yi Duan |
| author_facet | Youpeng Deng Shouwei Jiang Hanyu Duan Haonan Shao Yi Duan |
| author_sort | Youpeng Deng |
| collection | DOAJ |
| description | Abstract Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart disease, and hyperlipidemia. While alterations in gut bacteria are well‐documented, emerging evidence suggests that changes in gut viruses also contribute to these disorders. Bacteriophages, the most abundant gut viruses, influence bacterial populations through their lytic and lysogenic cycles, potentially modulating the gut ecosystem and metabolic pathways. Phage therapy, previously overshadowed by antibiotics, is experiencing renewed interest due to rising antibiotic resistance. It offers a novel approach to precisely edit the gut microbiota, with promising applications in metabolic diseases. In this review, we summarize recent discoveries about gut virome in metabolic disease patients, review preclinical and clinical studies of phage therapy on metabolic diseases as well as the breakthroughs and currently faced problems and concerns. |
| format | Article |
| id | doaj-art-0e93dcaeaea54efa85ee9d02c25fc487 |
| institution | OA Journals |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-0e93dcaeaea54efa85ee9d02c25fc4872025-08-20T02:23:09ZengWileyJournal of Diabetes1753-03931753-04072024-11-011611n/an/a10.1111/1753-0407.70024Bacteriophages and their potential for treatment of metabolic diseasesYoupeng Deng0Shouwei Jiang1Hanyu Duan2Haonan Shao3Yi Duan4Department of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei ChinaCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine University of Science and Technology of China Hefei ChinaCenter for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine University of Science and Technology of China Hefei ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei ChinaAbstract Recent advances highlight the role of gut virome, particularly phageome, in metabolic disorders such as obesity, type 2 diabetes mellitus, metabolic dysfunction‐associated fatty liver disease, and cardiovascular diseases, including hypertension, stroke, coronary heart disease, and hyperlipidemia. While alterations in gut bacteria are well‐documented, emerging evidence suggests that changes in gut viruses also contribute to these disorders. Bacteriophages, the most abundant gut viruses, influence bacterial populations through their lytic and lysogenic cycles, potentially modulating the gut ecosystem and metabolic pathways. Phage therapy, previously overshadowed by antibiotics, is experiencing renewed interest due to rising antibiotic resistance. It offers a novel approach to precisely edit the gut microbiota, with promising applications in metabolic diseases. In this review, we summarize recent discoveries about gut virome in metabolic disease patients, review preclinical and clinical studies of phage therapy on metabolic diseases as well as the breakthroughs and currently faced problems and concerns.https://doi.org/10.1111/1753-0407.70024bacteriophagegut viromemetabolic diseasesphage therapy |
| spellingShingle | Youpeng Deng Shouwei Jiang Hanyu Duan Haonan Shao Yi Duan Bacteriophages and their potential for treatment of metabolic diseases Journal of Diabetes bacteriophage gut virome metabolic diseases phage therapy |
| title | Bacteriophages and their potential for treatment of metabolic diseases |
| title_full | Bacteriophages and their potential for treatment of metabolic diseases |
| title_fullStr | Bacteriophages and their potential for treatment of metabolic diseases |
| title_full_unstemmed | Bacteriophages and their potential for treatment of metabolic diseases |
| title_short | Bacteriophages and their potential for treatment of metabolic diseases |
| title_sort | bacteriophages and their potential for treatment of metabolic diseases |
| topic | bacteriophage gut virome metabolic diseases phage therapy |
| url | https://doi.org/10.1111/1753-0407.70024 |
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