Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients
Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify th...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/5983574 |
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| author | Jianan Zhang Jing Li Shi Chen Linglin Gao Xiaoluan Yan Mingzhi Zhang Jia Yu Fenchun Wang Hao Peng |
| author_facet | Jianan Zhang Jing Li Shi Chen Linglin Gao Xiaoluan Yan Mingzhi Zhang Jia Yu Fenchun Wang Hao Peng |
| author_sort | Jianan Zhang |
| collection | DOAJ |
| description | Background. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. The association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P=0.004) in participants with low platelet count (<210 × 109/L) than in those with high platelet count (≥210 × 109/L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P=0.0001), and the interaction was significant (β = −0.021, P<0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. The association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. These results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation. |
| format | Article |
| id | doaj-art-0e8fa25e098f48449716f3a707cc41a7 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-0e8fa25e098f48449716f3a707cc41a72025-02-03T05:52:43ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/59835745983574Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive PatientsJianan Zhang0Jing Li1Shi Chen2Linglin Gao3Xiaoluan Yan4Mingzhi Zhang5Jia Yu6Fenchun Wang7Hao Peng8Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, ChinaDepartment of Cardiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, ChinaCenter for Disease Prevention and Control of Taicang City, Suzhou, ChinaCenter for Disease Prevention and Control of Taicang City, Suzhou, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, ChinaCenter for Disease Prevention and Control of Taicang City, Suzhou, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, ChinaBackground. Platelet consumption followed by homocysteine-induced endothelial injury suggests a crosstalk between platelet activation and homocysteine on hypertension. Platelet count has been found to modify the effect of folic acid on vascular health. However, whether platelet count could modify the contribution of homocysteine to blood pressure (BP) remains unclear. Methods. Leveraging a community-based cross-sectional survey in 30,369 Chinese hypertensive patients (mean age 62 years, 52% female), we examined the moderation of platelet count on the association between serum homocysteine and BP by constructing hierarchical multiple regression models, adjusting for conventional risk factors. If adding the interaction term of homocysteine and platelet count could explain more variance in BP and the interaction is significant, then we believe that moderation is occurring. Results. The association between serum homocysteine and diastolic BP was significantly stronger (β = 0.092 vs. 0.035, P=0.004) in participants with low platelet count (<210 × 109/L) than in those with high platelet count (≥210 × 109/L). Adding the interaction term of homocysteine and platelet count additionally explained 0.05% of the variance in diastolic BP (P=0.0001), and the interaction was significant (β = −0.021, P<0.001). Excluding participants receiving antihypertensive medications did not change our results. Conclusions. The association between homocysteine and BP was significantly stronger in participants with low vs. high platelet count and was partially moderated by platelet count. These results indicate that platelet count may be useful in the identification of individuals who are most beneficial to reducing-homocysteine treatments but this usefullness still needs further investigation.http://dx.doi.org/10.1155/2020/5983574 |
| spellingShingle | Jianan Zhang Jing Li Shi Chen Linglin Gao Xiaoluan Yan Mingzhi Zhang Jia Yu Fenchun Wang Hao Peng Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients International Journal of Hypertension |
| title | Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients |
| title_full | Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients |
| title_fullStr | Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients |
| title_full_unstemmed | Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients |
| title_short | Modification of Platelet Count on the Association between Homocysteine and Blood Pressure: A Moderation Analysis in Chinese Hypertensive Patients |
| title_sort | modification of platelet count on the association between homocysteine and blood pressure a moderation analysis in chinese hypertensive patients |
| url | http://dx.doi.org/10.1155/2020/5983574 |
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